Tretinoin 0.025% cream: what it’s used for and who it’s best for

Dr. Carolina Fernandez, board-certified dermatologist explains what tretinoin cream 0.025% is used for and what are its benefits.

Medically reviewed by:
Dr. Carolina Fernandez
Dermatologist

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Last updated: November 2025.

What is tretinoin 0.025% cream and who is it for?

Tretinoin 0.025% is usually a good strength for people who have never used retinoids before or those who have sensitive skin. Tretinoin 0.025% (sold under Retin-A and Tretin-X) is a topical cream or gel commonly prescribed by dermatologists to treat acne, fine lines, sun damage, and dark spots. It works by speeding up the skin’s cell turnover and stimulating collagen production.

Can you buy tretinoin cream 0.025% over-the-counter?

Unfortunately not, you need a prescription from a dermatologist to buy tretinoin 0.025%.

Can I get a personalized tretinoin-based formula via Miiskin?

Yes, via Miiskin your dermatologist can prescribe a tretinoin-based compounded formula to address common skin problems such as acne, anti-aging, melasma, acne scars and in some cases even rosacea. Your formula can include up to 5 ingredients such as niacinamide, azelaic acid, topical spironolactone, hydroquinone and kojic acid, among others. If you have tried a customized tretinoin 0.025 formula in the past and you would like to continue using it, please mention the ingredients of the formula you were using and your dermatologist will accommodate your wishes (or prescribe even something better) that works for you.

Important Disclaimer: Compounded medications are not reviewed by the FDA for safety or efficacy.

How to get a prescription for tretinoin 0.025%?

To get a prescription for tretinoin 0.025% you can have a virtual consultation with a board-certified dermatologist via Miiskin. The dermatologist will evaluate your request and If they think tretinoin 0.025% cream is suitable and safe for you, you can get your prescription. The consultation price with a board-certified dermatologist is $59 and medication renewals are $39.

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How is tretinoin 0.025 different from other cream strengths?

Tretinoin 0.025% is often prescribed as a starting point for individuals who are new to tretinoin or have sensitive skin, because side effects will be usually milder.

Higher tretinoin strength formulations, such as 0.05% and 0.1% are typically prescribed for individuals who have already gotten used to tretinoin 0.025% and their skin has responded well to it.

What are the advantages of using tretinoin 0.025 cream for the skin?

Tretinoin offers several key benefits for the skin, making it a widely prescribed treatment for various skin concerns:

It has anti-inflammatory properties: Its anti-inflammatory action helps reduce the redness, swelling, and irritation commonly associated with acne and other skin conditions.
Improves acne: Tretinoin helps unclog pores and prevent the formation of new acne lesions by increasing skin cell turnover, which reduces blockages in hair follicles.
Reduces fine lines and wrinkles: Tretinoin stimulates collagen production, helping to smooth fine lines and improve skin elasticity, making it a popular treatment for signs of aging.
Treats hyperpigmentation: It can lighten dark spots and even out skin tone by promoting faster skin cell renewal, which helps fade hyperpigmentation caused by acne, sun exposure, or melasma.
Enhances skin texture: Tretinoin smooths rough skin by removing dead cells and encouraging the growth of healthier, new skin, leading to a more refined texture.
Treats sun damage: Regular use of tretinoin can repair sun-damaged skin, reducing sunspots and improving the overall appearance of photoaged skin.

What ingredients can you use alongside tretinoin 0.025 cream?

When using tretinoin, certain ingredients can be used alongside to enhance its benefits and reduce potential irritation, particularly as tretinoin can sometimes cause dryness and sensitivity. Two of the most effective ingredients to pair with tretinoin are hyaluronic acid and niacinamide.

Hyaluronic Acid

Tretinoin pairs well with hyaluronic acid as it is a powerful humectant, meaning it draws moisture into the skin. Since tretinoin can lead to dryness and flakiness, hyaluronic acid helps to:

Boost hydration by holding up to 1,000 times its weight in water, keeping the skin plump and moisturized.
Reduces the risk of the skin becoming too dry or peeling, which is common when starting tretinoin.
Helps support the skin’s natural protective barrier, making it more resilient to the drying effects of tretinoin.

Niacinamide

Niacinamide (Vitamin B3) is a versatile ingredient with several skin benefits that complement tretinoin:

Works synergistically with tretinoin to fade hyperpigmentation and even out skin tone without increasing irritation.
Helps calm and soothe the skin, reducing redness and irritation that can be caused by tretinoin.
Strengthens the skin’s lipid barrier, helping to retain moisture and protect against environmental stressors, which can be especially important when using tretinoin.
Helps balance sebum production, which can prevent clogged pores and breakouts.

Topical spironolactone

Topical spironolactone is an emerging ingredient that works particularly well alongside tretinoin for acne-prone and oily skin types:

Helps regulate sebum production and reduce hormonal acne breakouts.
Has anti-androgenic properties that target one of the root causes of hormonal acne.
Works well with tretinoin to improve overall skin texture and reduce the appearance of active blemishes and post-acne marks.

Important Disclaimer: Topical spironolactone is not reviewed by the FDA for safety or efficacy.

How to apply tretinoin 0.025%?

If you’re new to tretinoin, follow your healthcare provider’s instructions. However, here’s a general approach for beginners.

After cleansing, wait for 20 minutes then apply hyaluronic acid every evening to damp skin to lock in moisture, followed by tretinoin. Finish with a moisturizer to further hydrate and soothe. Every morning apply sunscreen with at least SPF 50 and reapply every two hours when exposed to the sun.

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Provider & Prescription Information

Miiskin connects patients with independent dermatologists who provide care through their private practices. Compounded prescriptions can be ordered via Miiskin and are dispensed by Foothills pharmacy. Standard medications can be issued for any local pharmacy.

Frequently asked questions about tretinoin 0.025%

How often should I apply tretinoin 0.025% cream?

First 2 to 4 weeks: Apply tretinoin to your face twice a week in the evenings. Layer between hyaluronic acid and niacinamide.
Following 2 weeks: If your skin is tolerating the product well, increase application to every other night, continuing to apply a moisturizer afterward. Layer between hyaluronic acid and a moisturizer.
After 6 to 8 weeks: If your skin adapts without irritation, start applying tretinoin every night, always following with a hydrating cream containing hyaluronic acid or moisturizer. Layer between hyaluronic acid and niacinamide.
Adjust as needed: If your skin becomes overly dry or irritated at any point, reduce usage. Skip tretinoin on those nights and apply only a moisturizer to allow your skin to recover.

What ingredients to avoid when using tretinoin?

Other retinoids: Avoid combining tretinoin with retinol, tazarotene, trifarotene, or adapalene to prevent excessive irritation.
Exfoliating acids: If using glycolic, lactic, or salicylic acid, apply them on alternate days to reduce the risk of irritation.
Benzoyl peroxide: Combining benzoyl peroxide with tretinoin may reduce the effectiveness of tretinoin, so it’s best to avoid using them together unless they are combined in the same medication.

Who should avoid tretinoin 0.025%?

Women who are pregnant, planning to become pregnant, or breastfeeding, as tretinoin is a form of vitamin A that may pose a risk during pregnancy.
Have eczema, rosacea, or very sensitive skin, since tretinoin can worsen irritation and redness.
Are currently using other strong exfoliants or topical acne medications (such as benzoyl peroxide, salicylic acid, or alpha hydroxy acids) without your dermatologist’s guidance.
Have sunburned, broken, or inflamed skin, as tretinoin can further irritate damaged areas.
Have a known allergy or hypersensitivity to tretinoin

What precautions should I take when using tretinoin 0.025%?

When using tretinoin 0.025%, start slowly to allow your skin to adjust, applying a pea-sized amount to clean, dry skin every two to three nights before gradually increasing to nightly use. Always use a gentle moisturizer to prevent dryness and flaking, and apply sunscreen daily since tretinoin increases sun sensitivity. Avoid combining it with harsh exfoliants or other active ingredients unless advised by your dermatologist, and never use it if you are pregnant or breastfeeding. Consistent use, sun protection, and patience are key to achieving the best results safely.

What are the potential side effects of tretinoin 0.025%?

Tretinoin, while highly effective for various skin conditions, can cause several potential side effects, especially during the initial stages of use. Some common and less common side effects include:

Skin irritation: Redness, peeling, dryness, and itching are among the most common side effects, especially in the early stages of treatment as the skin adjusts to the medication.
Increased sensitivity to sunlight: Tretinoin makes the skin more sensitive to UV rays, leading to a higher risk of sunburn. It’s essential to use sunscreen regularly while using tretinoin.
Flaking and peeling: As tretinoin accelerates skin cell turnover, you may experience flaking or peeling, which can result in rough patches or dry skin.
Temporary worsening of acne: Some users experience an initial breakout or worsening of acne before improvements are seen, this is known as the tretinoin purge, and it is a common skin reaction when you use tretinoin for the first time.
Dryness: In rare cases, excessive dryness or scaling may occur, leading to discomfort or irritation.