Get a tretinoin prescription online

24-48hr response

Nationwide service

*Average online dermatologist response time from July-September 2026: 18.6 hours

Board-certified dermatologists
No medication subscriptions
Choice of generic or customized formulas

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Tretinoin is commonly prescribed as part of treatment for the conditions below.

Available strengths:
Tretinoin 0.025% | Tretinoin 0.05% | Tretinoin 0.1%

Miiskin platform displaying facial photo upload for an online dermatology assessment, shown with Tretinoin 0.05% prescription cream and Foothills skincare product

Content last updated: October 2026

Medically reviewed by:
Dr. Anna Chacon
Dermatologist

How to get tretinoin online?

Tretinoin is prescription-only in the US, so you need a prescription before you can buy it. The quickest way is an online consultation with a board-certified dermatologist licensed in your state. You don’t need a video call. If tretinoin is right for your skin, your prescription is sent to the pharmacy you choose, usually within 24–48 hours.

Submit your skin concern

Answer a short medical questionnaire and upload a few photos of your skin. It takes about 5 minutes, with no video call needed.

Dermatologist review

A board-certified dermatologist licensed in your state reviews your case. Average response time is less than a day.

Get your treatment plan

If tretinoin suits your skin, you’ll receive a prescription for generic, branded or customized tretinoin. Pick it up locally or have it delivered.

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Tretinoin treatment options

You can request FDA-approved tretinoin or a customized tretinoin formula. Your dermatologist will recommend what’s best for your skin.

FDA-approved tretinoin

You can choose generic or brand-name tretinoin, which can be filled at any pharmacy nationwide. FDA-approved tretinoin has been reviewed for safety, effectiveness and quality, and has been used in dermatology for over 50 years.

Tretinoin 0.025% (Generic Retin-A®)
Tretinoin 0.05% (Generic Retin-A®)
Tretinoin 0.1% (Generic Retin-A®)
Retin-A Micro® (Tretinoin microsphere gel)
Altreno® (Tretinoin lotion)
Refissa® (Tretinoin cream)

Prescribed only if medically appropriate. Your dermatologist decides which product and strength fits your skin.

Customized tretinoin formulas

Customized formulas combine tretinoin with other active ingredients in one product tailored to your skin. They’re prepared by our trusted partner, Foothills Pharmacy, and delivered to your door. Most formulas are $48.99 with delivery included.

Niacinamide
Azelaic acid
Hydroquinone
Kojic acid
Ascorbic acid
Clindamycin
Topical spironolactone
Hydrocortisone
Pracasil plus

Compounded medications are not reviewed by the FDA for safety or efficacy.

How much does a tretinoin prescription cost?

A first online consultation with a board-certified dermatologist on Miiskin costs $59–$79, depending on the dermatologist you choose. Prescription renewals cost $39-$49. There’s no subscription, and you only pay for the consultation you need.

Where can I fill my tretinoin prescription?
For generic or branded tretinoin, your dermatologist can send the prescription to any pharmacy in the US, including your local pharmacy or an online pharmacy that delivers. For a customized tretinoin formula, choose Foothills as your pharmacy. Most Foothills formulas cost $48.99, with free delivery.

Medication is paid separately at the pharmacy. Your dermatologist decides whether tretinoin is right for you.

How does Miiskin compare to other online services for tretinoin?

Most online skincare services offer tretinoin only in their own compounded formulas, sold by subscription. Here’s how Miiskin compares on the things that matter when you’re getting a tretinoin prescription online.

Swipe to compare →

Feature	Miiskin	Nurx	Agency	Hers	Curology
Provider type	Board-certified dermatologist	Physician, NP or PA	Physician, NP or PA	Physician or NP	Physician, NP or PA
Choose your dermatologist	Yes	No	No	No	No
Generic (FDA-approved) tretinoin	Yes	Yes	No*	No*	No*
Customized tretinoin formulas	Yes	Yes	Yes	Yes	Yes
Tretinoin strengths	0.025%, 0.05%, 0.1% or custom	0.025%, 0.05%, 0.1%	Custom only	Custom only, up to 0.09%	Custom only
Choice of pharmacy	Yes	No	No	No	No
Subscription required	No	Yes**	Yes	Yes	Yes

*Tretinoin is offered only in compounded custom formulas. Compounded medications are not reviewed by the FDA for safety or efficacy.

**Advertised as “no subscription needed,” but medication ships and is billed automatically unless paused or canceled.

Comparison based on information published on each service’s website, October 2026.

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What is tretinoin?

Tretinoin (generic version of Retin-A) is a topical prescription medication widely used by dermatologists to treat acne, hyperpigmentation, wrinkles and sun damage¹.

Tretinoin works by accelerating the lifecycle of skin cells and boosting new collagen formation. It belongs to a family of synthetic and natural compounds called retinoids that are derived from Vitamin A².

Benefits of tretinoin

Stimulates collagen for firmer skin

Reduces fine lines and wrinkles

Smooths skin texture and tone

Fades dark spots and discoloration

Unclogs pores and reduces breakouts

Prevents future acne formation

What is tretinoin cream or gel used for?

Tretinoin is used by dermatologists for the treatment of:

Acne and acne scars

Facial wrinkles

Skin roughness

Hyperpigmentation³

Brand names of tretinoin gels or creams

Retin – A
Altreno
Atralin
Avita

Refissa
Renova
Tretin – X
Retin – A micro

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Tretinoin explained

How does tretinoin work?

Tretinoin stimulates cell renewal in the epidermis, enhancing the cell layer, reducing pigmentation and normalizing sun-damaged cells⁴.

Tretinoin also works in the dermis promoting the production of collagen and elastin thickening the dermal layer and making the skin appear more plump⁵.

According to multiple research, tretinoin gels and creams are a safe and effective therapeutic modality for the long-term treatment of acne and photoaging.^{6 78}

workflow management between primary care and dermatologists

Most common tretinoin strengths prescribed

Tretinoin Cream 0.025%

Tretinoin cream at 0.025% concentration is a gentler option, often recommended for patients new to tretinoin or those with sensitive skin. Its lower strength allows for a gradual introduction to tretinoin, reducing the chance of irritation. It’s commonly used for mild concerns such as fine lines, uneven skin tone, and mild acne.

Tretinoin Cream 0.05%

Tretinoin cream 0.05% works faster and produces more visible results than the 0.025% cream. It’s a moderate-strength option suitable for addressing more prominent signs of aging, moderate acne, and persistent hyperpigmentation. Although it carries a higher risk of side effects like dryness, following your doctor’s guidance can help manage any reactions and maximize its effectiveness.

Tretinoin Cream 0.1%

Tretinoin cream 0.1% is considered high-strength and is typically reserved for more intense treatment needs. It is often recommended for individuals with more severe skin concerns, such as deep wrinkles, pronounced signs of aging, or stubborn acne that requires stronger intervention.

Still not sure which strength fits your skin?

Our tretinoin strengths guide breaks down every concentration in detail and explains when it’s the right time to move up.

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Warnings, side effects and purging

Warning and precautions when using tretinoin creams or gels

This medication should only be used under medical supervision and it is advised that women use effective contraception when using tretinoin.

Tretinoin is considered teratogenic, and therefore it cannot be used by women who want to become pregnant, are pregnant, or are breastfeeding because it may cause serious harm to the fetus¹³ ^14.

Tretinoin is likely to make your skin more sensitive to sunlight so you should apply sunscreen with SPF 50 factor every morning while using this product and reapply every two hours when outdoors.

Tretinoin may cause skin irritation when you first start using it, follow the precise instructions of your healthcare provider to minimize unwanted side effects.
Do not combine tretinoin with other acne or pigmentation medications, unless indicated by your doctor.

Side effects of tretinoin

Redness
Peeling
Itching
Burning/Stinging
Dryness¹⁵

What is the tretinoin purge?

The tretinoin purge (also known as tretinoin uglies) is a very common skin reaction that occurs when a patient uses tretinoin for the first time.

Learn more about the tretinoin purge →

How to get started once tretinoin is prescribed?

You should always follow the precise instructions of your healthcare provider, because your treatment plan will depend on your skin condition and your skin type. However, as a general rule, if you have never used tretinoin, here is a good way to start.

First 2 to 4 weeks:
Apply tretinoin .025% two nights per week in the evenings
Following 2 weeks:
Apply tretinoin every other night
After 6 to 8 weeks of use:
If your skin tolerates the product well, apply the product every night

It is also important to find a balance that is right for you. Your skin may not tolerate the application of tretinoin every day even after weeks of use and you may notice that your skin improves by applying tretinoin every other day instead of daily.

How to use Tretinoin correctly

Watch this 2-minute video where doctor Anna Chacon, board-certified dermatologist in the Miiskin network, explains how to use tretinoin the proper way to minimize the potential of irritation.

Click to read video transcript

How to Use Tretinoin
– Start with a gentle cleanser.
– Wash your face with lukewarm water and pat dry with a soft towel.
– Always make sure your skin is completely dry before applying tretinoin — wait about 15 to 20 minutes. This helps minimize irritation.
– Before applying tretinoin, always start with a gentle, non-comedogenic moisturizer. This helps protect your skin barrier and reduces dryness and peeling.
– Next, squeeze out a pea-sized amount — that’s really all you need for your entire face. Dot the tretinoin across your forehead, both cheeks, nose, and chin. Then gently spread it evenly over your entire face.
– Avoid the corners of your mouth, the creases around your nose, and the delicate skin around your eyes — these areas are more prone to irritation.
– Apply an additional layer of moisturizer across the face and neck. This is optional but recommended, especially if you have sensitive skin. You can also use a hyaluronic serum instead of a moisturizing cream.
– Remember, tretinoin takes time to work. You may not see results for several weeks, but consistency is key.
– Tretinoin requires a prescription from a dermatologist. If you are interested in getting a personalized tretinoin formula — with up to three additional ingredients for your skin — I am here to help.

Click the link to start your consultation today.

What ingredients can be safely combined with tretinoin?

Sunscreen SPF 50

Hyaluronic acid

Non-greasy moisturizer

Azelaic acid

Niacinamide

Peptides

Ceramides

What ingredients should not be combined with tretinoin?

Benzoyl peroxide*
Glycolic acid*
Lactic acid*
Salicylic acid*

Retinol
Tazarotene
Trifarotene
Adapalene

*Unless instructed by a dermatologist

Got more questions about how to get a tretinoin (Retin-A) prescription?

Dr. Anna Chacon, board-certified dermatologist, answers the most common questions about getting a tretinoin prescription online.

Where can I get Tretinoin Rx online?

You can get Tretinoin Rx online through Miiskin. Start a consultation with a board-certified dermatologist licensed in your state, share a few photos and answer a short questionnaire, with no video call needed. If tretinoin is right for your skin, your dermatologist can prescribe generic tretinoin, a brand-name product such as Retin-A®, or a customized formula, and send it to any pharmacy you choose. A consultation costs $59–$79 with no subscription, and most customized formulas from Foothills Pharmacy are $48.99 with delivery included.

Which is better: a customized tretinoin formula or a generic tube?

Both options can be effective, but the better choice depends on your skin’s needs. A generic tretinoin tube is a simple, FDA-approved medication with a fixed strength, making it reliable and affordable. A customized tretinoin formula, on the other hand, can combine tretinoin with other ingredients like niacinamide, azelaic acid, or topical spironolactone to target multiple concerns at once. Custom formulas may offer a more tailored experience, especially if you struggle with irritation or have several skin issues to address, while generic tretinoin is ideal if you want a straightforward, proven treatment.

What’s the best way to get tretinoin online without insurance?

An online dermatology consultation is often one of the most affordable ways to get a tretinoin prescription. Miiskin connects you with board-certified dermatologists who offer affordable consultations without requiring insurance or a subscription. Your dermatologist can send a prescription for generic tretinoin to any pharmacy you choose, allowing you to compare prices or use a discount card to save on medication costs.

Can I get tretinoin online without a subscription?

Yes. Miiskin doesn’t require a subscription. You pay for each consultation and buy your tretinoin at the pharmacy you choose. Many other online services sell tretinoin only as part of a monthly compounded formula plan.

How much are customized tretinoin-based formulas via Miiskin?

Most customized Foothills formulas are $48.99 for a 30-gram tube, a few advanced formulas are priced at $58.99. This price includes free UPS shipping.

Which online services prescribe tretinoin?

Several telehealth services prescribe tretinoin, including Miiskin, Nurx, Agency, Hers and Curology. The main differences are who reviews your case, whether you can get generic FDA-approved tretinoin, and whether a subscription is required. Miiskin is the only one in our comparison where you choose your own board-certified dermatologist and your pharmacy.

How long will it take to get the prescription for my tretinoin?

Most users receive their tretinoin prescription within 24 hours, but you need to wait up to 2 business days after submitting a online consultation.

Where can I buy tretinoin?

You can buy tretinoin at any US pharmacy once you have a prescription. That includes local chains, independent pharmacies and online pharmacies that deliver. To get a prescription without visiting a clinic, you can consult a board-certified dermatologist online through Miiskin. Avoid websites that sell tretinoin without a prescription, since the product may be counterfeit or unsafe.

Can I use tretinoin long-term?

Yes – tretinoin can be used long-term under the guidance of a healthcare professional. In fact, many dermatologists recommend ongoing use to maintain results for acne control, skin texture improvement, and anti-aging benefits.

That said, tretinoin should be used consistently but carefully: most people tolerate it well once their skin adjusts, but it can cause dryness, peeling, or irritation, especially in the early weeks. Using moisturizer, sunscreen, and following the prescribed strength and frequency help minimize side effects.

Does tretinoin expire, and how do I get a refill?

Yes. Every tube of tretinoin has an expiration date printed on it, and expired tretinoin may be less effective. If you need more, you can renew your prescription online through Miiskin, with no new full consultation needed if your dermatologist considers it appropriate. The prescription is sent to the pharmacy you choose.

Is generic tretinoin as good as Retin-A?

Yes. Generic tretinoin contains the same active ingredient at the same strength as Retin-A, and the FDA approves generics as equivalent to the brand-name product. Generic tretinoin usually costs much less. Through Miiskin, your dermatologist can prescribe generic, brand-name or customized tretinoin, depending on what suits you best.

Can I get a tretinoin formula similar to the one I get from Curology, Agency, Hers or Apostrophe?

Yes. If you use a customized tretinoin formula from Curology, Agency or Hers, or used one from Apostrophe before it closed, you can share its ingredients and strengths during your Miiskin consultation. A board-certified dermatologist will review your skin and can prescribe a similar customized formula with up to 5 active ingredients, such as tretinoin with niacinamide, azelaic acid or clindamycin. Formulas are prepared by Foothills Pharmacy and most cost $48.99 with delivery included, with no subscription.

References:
¹https://www.ncbi.nlm.nih.gov/books/NBK557478/
²https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9112391/
³https://www.ncbi.nlm.nih.gov/books/NBK557478/
⁴https://www.ncbi.nlm.nih.gov/books/NBK557478/
⁵https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9112391/
⁶https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9112391/
⁷https://jamanetwork.com/journals/jamadermatology/article-abstract/553009
⁸https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574737/
⁹https://link.springer.com/article/10.2165/00002512-199506060-00008
¹⁰https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225141/
¹¹https://pubmed.ncbi.nlm.nih.gov/16045694/
¹²https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225141/
¹³https://rarediseases.info.nih.gov/diseases/517/fetal-retinoid-syndrome
¹⁴https://pubmed.ncbi.nlm.nih.gov/26897386/
¹⁵https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9112391/