Home / Acne / Medications Acne Medications Most Common Oral and Topical Medications used in the Treatment of Acne Vulgaris (also referred to as Pimples). DERMATOLOGY | SKIN CANCER | MELANOMA | MOLES | ACNE | ACNE MEDICATIONS Featured Article EDUCATIONAL ARTICLE Clindamycin Gels and Creams for Acne Clindamycin Gels and Creams are a common prescription medication used to treat mild to moderate acne. It is sold as a stand-alone ingredient in topical solutions or as a compound with Benzoyl Peroxide and Tretinoin. Explore More Topics EDUCATIONAL ARTICLE Tretinoin VS. Retinol Retinol and Tretinoin are both Vitamin A derivatives used for anti-aging and combat acne breakouts. Tretinoin needs a prescription, whereas Retinol is easily accessable. Latest Articles EDUCATIONAL ARTICLE Topical and Oral Spironolactone for Treating Hormonal Acne Spironolactone, a topical and oral medication, is used to treat hormonal acne because it lowers testosterone levels, which in turn reduces oil production and acne outbreaks.