Tazarotene: a dermatologist’s guide for patients

Acne

Tazarotene is approved for the topical treatment of mild to moderate acne. It works by normalizing follicular keratinization (the process that clogs pores) and reducing inflammatory lesions.

Several studies show that tazarotene gel reduces acne lesions more effectively than some other retinoids like adapalene or tretinoin in patients.

Learn more

Is tazarotene better for acne?

Tazarotene is the most potent retinoid, but does it work for acne? Dr. Chacon explains when and how to use it for acne and how to get a prescription.

Photo‑damaged skin / wrinkles and pigmentation

Tazarotene has also been used off‑label for improving sun‑damaged skin, fine lines, and pigment changes, by stimulating collagen production and enhancing skin turnover.

Plaque psoriasis

This is a chronic, immune mediated condition where skin cells grow too quickly, leading to thick, red, scaly plaques. Tazarotene modulates abnormal cell growth and inflammation in psoriatic skin.

Multiple studies show that applying tazarotene daily reduces the size, thickness, and scaling of psoriatic plaques. It can be used with or without a corticosteroid, but combining with a steroid can improve efficacy and reduce irritation.

Request a tazarotene prescription online

Have a consultation with a dermatologist via Miiskin to request a prescription for tazarotene cream and choose between a generic or customized medication.

Start tazarotene consult

No, tazarotene is not available over the counter in the United States. It’s a prescription-only medication because it’s a strong retinoid that can cause irritation, dryness, and other side effects if not used correctly. Besides, tazarotene is considered teratogenic which means it can cause birth defects if used during pregnancy. A dermatologist needs to evaluate your skin condition and decide if tazarotene is appropriate and safe for you to use.

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Is tazarotene cream OTC?

Have an online consultation with a dermatologist through Miiskin and, if prescribed, purchase tazarotene directly on the platform starting at $48.99.

How to get a prescription for tazarotene online?

To get a prescription for tazarotene cream online, you can consult a dermatologist via Miiskin. You just need to upload photos of your skin and fill out a brief medical questionnaire. Your dermatologist will review your case and, if appropriate, prescribe tazarotene. First time consultation is $59 and prescription renewal visits are around $39.

Request a tazarotene prescription online

Have a consultation with a dermatologist via Miiskin to request a prescription for tazarotene cream and choose between a generic or customized medication.

Start tazarotene consult

Through Miiskin, you can purchase generic tazarotene cream from Foothills Pharmacy for $48.99. A combination formula that includes tazarotene and Pracasil plus is available for $68.99. Medications are sold on-demand, with no monthly subscription required.

Important Disclaimer: Compounded medications are not reviewed by the FDA for safety or efficacy.

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Tazarotene cream price

Historically, tazarotene creams and gels have been more expensive than tretinoin, but this is no longer the case in 2026. Find out why.

We have complied the best tazarotene coupons so you can compare them and make an informed decision. Via Miiskin, you can purchase generic tazarotene cream from Foothills Pharmacy for $48.99 and some formulas are available for $68.99.

Important Disclaimer: Compounded medications are not reviewed by the FDA for safety or efficacy.

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Tazarotene cream coupons

Find the best tazarotene coupons in 2026 to lower the cost of your prescription and buy tazarotene at a more affordable price without paying full retail costs.

Dr. Om says that tazarotene usually starts to show improvement in your skin after 1 to 2 weeks, but it can take up to 4 to 8 weeks or longer for full results, depending on what you’re treating (like acne or psoriasis). He also added that it’s common to experience some irritation, dryness, or even a temporary worsening of symptoms in the first few weeks (this is part of the skin adjusting) and doesn’t mean it’s not working. Sticking with it consistently, as directed by your provider, is key to seeing the best results.

Dr. Amit Om, explains how to use tazarotene step by step.

1. Cleanse gently
Wash your face with a mild, non-foaming cleanser and pat dry. Wait about 10–20 minutes to make sure your skin is completely dry since applying tazarotene to damp skin increases the risk of irritation.

2. Apply a thin layer of moisturizer
Apply a light layer of a gentle moisturizer to your entire face. This creates a “buffer” to reduce dryness, especially if you’re just starting out.

3. Apply a pea-sized amount of tazarotene
Squeeze a pea-sized amount onto your fingertip, this is enough for the entire face. Dot it onto your forehead, cheeks, chin, and nose, then gently spread a thin, even layer, avoiding the eyes, lips, and corners of the nose.

4. Follow with another layer of moisturizer
One or two minutes after the cream absorbs, apply another layer of moisturizer over your face. This is the second part of the “sandwich” and helps lock in hydration while minimizing irritation.

5. Use only at night
Tazarotene should only be used once daily at bedtime, as it can make your skin more sensitive to sunlight.

6. Use sunscreen every morning
Apply a broad-spectrum sunscreen (SPF 50) every morning (even on cloudy days)  to protect your skin from increased sun sensitivity caused by tazarotene.

Extra tips from Dr. Om:

Do not use during pregnancy: This drug is teratogenic which means you cannot use it if you are trying to become pregnant, are pregnant or breast feeding.

Start slow: Use it 2–3 nights per week at first, and increase as your skin gets used to it.

Avoid harsh products: Stop using exfoliants, alcohol-based toners, or strong acids while your skin adjusts.

Be patient: It may take 6–12 weeks to see results, and some irritation early on is normal.

Request a tazarotene prescription online

Have a consultation with a dermatologist via Miiskin to request a prescription for tazarotene cream and choose between a generic or customized medication.

Start tazarotene consult

Tazarotene is available in several topical formulations, including:

• Cream – typically more moisturizing and better for dry or sensitive skin
• Gel – lighter and often preferred for oily or acne-prone skin
• Foam – spreads easily and may be useful for larger or hair-bearing areas like the scalp
• Lotion – a newer formulation combining efficacy with improved tolerability

Tazarotene comes in the following concentrations:

• 0.1% – standard strength for most skin conditions
• 0.05% – lower strength, often used to start treatment or for sensitive skin
• 0.045% – available in newer lotion formulations designed for better tolerability

Dr. Om explains that once open, you should not use your tazarotene for more than 12 months to ensure maximum potency and reduce the risk of contamination. Always store it at room temperature, away from heat, moisture, and direct sunlight to preserve its stability.

The expiration date is printed on the packaging, and it’s important not to use the medication past that date, as its effectiveness and safety may decrease. 

Retinoids play an important role in treating a wide range of skin concerns, including acne, signs of aging, and uneven skin texture. Among them, tazarotene is a powerful and effective option, commonly used for acne, psoriasis, and anti-aging. While it is just one of several retinoids available—each with its own strengths—as a general rule, you should avoid using two different retinoids at the same time. Because they work in similar ways, combining retinoids can increase the risk of skin irritation.

Tazarotene vs tretinoin

Dr. Om says that tazarotene and tretinoin are both prescription topical retinoids used for acne and signs of aging, but studies show tazarotene may be slightly more effective in reducing acne lesion counts compared to tretinoin, though it also tends to be more irritating and less well tolerated early in treatment. In addition, tazarotene is also FDA‑approved for psoriasis in addition to acne, while tretinoin is primarily used for acne and photoaging.

Learn more

Tazarotene vs tretinoin

Tazarotene and tretinoin are two common prescription drugs used to treat wrinkles and acne. Although relatively similar, one is stronger than the other one showing faster results but it also irritates the skin a bit more.

Tazarotene vs adapalene

Dr. Om explains that compared with adapalene, tazarotene tends to be more potent against acne lesions but also has a higher irritation profile, whereas adapalene is a chemically stable retinoid that causes less irritation and can be combined directly with benzoyl peroxide; adapalene is often chosen first for sensitive or mild‑to‑moderate acne.

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Adapalene vs tazarotene

Dr. Allen breaks down whether tazarotene or adapalene is better for acne and anti-aging—and how to choose the right retinoid.

Tazarotene vs retinol

Dr. Om says that tazarotene is a prescription‑strength retinoid that works directly as an active molecule in the skin, making it substantially more potent than over‑the‑counter retinol, which must first convert into active retinoic acid and therefore acts more slowly and with far less irritation; retinol is often used for mild anti-aging concerns.

Tazarotene vs trifarotene (Aklief) 

Dr. Om explains that Tazarotene and trifarotene are both prescription topical retinoids for acne, but trifarotene is a newer “fourth‑generation” retinoid that selectively targets the RAR‑γ receptor, potentially offering effective acne treatment with a more targeted action and possibly improved tolerability, though long‑term comparative data versus tazarotene are still emerging.

Tazarotene vs isotretinoin

Dr. Om says although they are both retinoids, they are very different. Tazarotene is a topical retinoid applied directly to the skin for acne, while isotretinoin is an oral prescription medication reserved for severe or cystic acne that has not responded to topical therapy. Isotretinoin works systemically to dramatically reduce oil production and often leads to long‑term remission but requires strict medical monitoring due to significant potential systemic side effects.

Acne is often treated using a combination of two or more medications at the same time, a strategy commonly known as combination treatment.

Combination therapy is designed to target the different factors that contribute to acne, including excess oil production, acne-causing bacteria, inflammation, and abnormal skin cell turnover.

By combining medications that work in different ways, dermatologists can often achieve more effective and well-rounded results than with a single treatment alone.

For example, a common approach may include using a topical retinoid such as tazarotene alongside clindamycin. This helps address both clogged pores and bacterial overgrowth. When used appropriately, combination therapy can improve treatment effectiveness, speed up visible results, and reduce the risk of antibiotic resistance associated with antibiotic-only treatments.

Tazarotene + hydroquinone

Dr. Om says that tazarotene and hydroquinone can be combined, and dermatologists often use this pairing to treat melasma, post-inflammatory hyperpigmentation (PIH), and uneven skin tone. Tazarotene increases skin cell turnover, helping fade dark spots more quickly, while hydroquinone directly lightens hyperpigmented areas by inhibiting melanin production. This combination is often used short-term and under close supervision.

Your dermatologist may also prescribe a compounded formula that includes tazarotene and hydroquinone.

Important Disclaimer: Compounded medications are not reviewed by the FDA for safety or efficacy.

Tazarotene + Pracasil plus

Dr. Om explains that tazarotene and pracasil plus are often used together to treat acne scars, especially indented types like icepick or boxcar scars. Tazarotene promotes collagen production and increases cell turnover, which can gradually improve skin texture and reduce the depth of scars over time. Pracasil Plus supports this process by hydrating the skin, softening scar tissue, and minimizing irritation caused by tazarotene. Together, they help enhance skin healing while making the treatment more tolerable, especially for those with sensitive or scar-prone skin.

Your dermatologist may also prescribe a compounded formula that includes tazarotene and pracasil plus.

Important Disclaimer: Compounded medications are not reviewed by the FDA for safety or efficacy.

Tazarotene + niacinamide

The combination of tazarotene and niacinamide is commonly used for the treatment of acne and signs of aging, as these ingredients complement each other well. When tazarotene and niacinamide are combined, their synergistic effects can provide multiple skin benefits, including reduced skin irritation, enhanced treatment efficacy, a simplified skincare routine, and a more affordable treatment option.

Your dermatologist may also prescribe a compounded formula that includes tazarotene and niacinamide.

Important Disclaimer: Compounded medications are not reviewed by the FDA for safety or efficacy.

Provider & Prescription Information

Miiskin connects patients with independent dermatologists who provide care through their private practices. Compounded prescriptions can be ordered via Miiskin and are dispensed by Foothills pharmacy. Generic prescriptions can be filled at any local or online pharmacy.

Got more questions about tazarotene?

Can you use tazarotene if you have rosacea or sensitive skin?

Tazarotene is generally not recommended for people with rosacea or very sensitive skin, as it can cause irritation, redness, and peeling, especially in already inflamed or reactive skin. If your skin is prone to stinging, flushing, or dryness, using tazarotene may worsen these symptoms. 

However, in some cases, a dermatologist might prescribe it with special instructions, like using it every other night, layering it with a moisturizer, or combining it with anti-inflammatory treatments. Always consult a dermatologist before using tazarotene if you have rosacea or sensitive skin.

Can tazarotene be used for acne?

Dr. Om explains that tazarotene is FDA-approved for the treatment of acne and is often prescribed for mild to moderate cases. It works by increasing skin cell turnover, preventing clogged pores, and reducing inflammation. While some patients experience dryness and irritation at first, tazarotene is highly effective and is often used when other topical treatments haven’t worked well.

Can tazarotene be used for wrinkles?

Tazarotene is also approved for reducing fine lines and wrinkles, and Dr. Om notes that it can improve skin texture and tone by stimulating collagen production and speeding up cell renewal. It’s often used in patients with sun damage or signs of aging, although it may cause dryness or peeling, especially in the early stages of treatment.

Does tazarotene fade dark spots (melasma)?

Dr. Om explains that tazarotene is not FDA-approved for melasma, but it can be used off-label in combination with other treatments, such as hydroquinone. It may help fade dark patches by increasing skin turnover, but because it can irritate the skin, it should be used cautiously, especially in patients with darker skin tones who are more prone to post-inflammatory hyperpigmentation.

Can tazarotene be used for post-inflammatory hyperpigmentation (PIH)?

Dr. Om says that tazarotene can be helpful in treating PIH by promoting skin renewal and fading discoloration over time. However, it must be used carefully, often in combination with other agents, to avoid irritation, which can worsen pigmentation. A tailored routine with moisturizers and sun protection is important when using tazarotene for these concerns.

Can tazarotene be used for seborrheic keratosis?

Tazarotene is not typically used for seborrheic keratosis, Dr. Om explains, as these benign growths don’t usually respond to topical retinoids. Instead, dermatologists use procedures like cryotherapy or curettage to remove them. While retinoids help with many skin conditions, seborrheic keratosis requires a different treatment approach.

Can tazarotene remove acne scars?

Dr. Om shares that tazarotene can help improve the appearance of mild to moderate atrophic scars over time by increasing collagen production and smoothing skin texture. It’s often combined with other treatments like micro-needling or chemical peels to enhance results in a full acne scar treatment plan.

Can tazarotene be used for ichthyosis?

Tazarotene may be used off-label for certain forms of ichthyosis, Dr. Om says, because of its ability to normalize skin cell turnover and reduce thick scaling. However, it can be irritating on already sensitive or dry skin, so its use should be closely monitored and paired with moisturizing creams to improve tolerance.

Can tazarotene be used for keratosis pilaris?

Dr. Om explains that tazarotene is used off-label in cases that are resistant to standard therapies. By promoting exfoliation and reducing keratin buildup, it may help smooth the bumps, but gentler options like lactic acid or urea creams are usually tried first due to the risk of irritation.

Is tazarotene stronger than tretinoin?

Yes, tazarotene is generally considered stronger than tretinoin, according to Dr. Om. It often shows faster results for acne, pigmentation, and aging but is also more likely to cause dryness and irritation. Dermatologists may recommend tazarotene for patients who have already used tretinoin successfully and can tolerate a more potent retinoid.

Is tazarotene a retinoid?

Dr. Om confirms that tazarotene is a retinoid, specifically a third-generation topical retinoid derived from vitamin A. It’s designed to treat acne, psoriasis, and signs of aging by affecting how skin cells grow and shed, helping to keep pores clear, smooth texture, and even out skin tone.

Can tazarotene be used while pregnant?

Dr. Om clearly advises against using tazarotene during pregnancy. Tazarotene is classified as a Category X medication, meaning it has shown potential to cause harm to a developing fetus in animal studies. Even though it’s applied topically and absorbed in small amounts, there is still enough risk that it should be avoided entirely during pregnancy. Patients who are pregnant or planning to become pregnant should not use tazarotene and talk to their dermatologist about safer alternatives.

What is better than tazarotene?

Dr. Om explains that whether something is “better” than tazarotene depends on the skin condition and individual tolerance. For severe or cystic acne, oral isotretinoin may be more effective overall. For sensitive skin or beginners, milder retinoids like adapalene or tretinoin may be better tolerated. In anti-aging routines, some patients prefer tretinoin or retinol due to less irritation, while others benefit more from tazarotene’s stronger effects. The best choice is always based on the patient’s skin type, goals, and how well they tolerate treatment.

Which is better for acne, tretinoin or tazarotene?

Both tazarotene and tretinoin are effective for acne, but Dr. Om says tazarotene is generally considered stronger and may work faster in reducing acne lesions. However, it also tends to cause more irritation, so tretinoin may be a better option for patients with sensitive skin or those new to retinoids. Dermatologists often start with tretinoin and move to tazarotene if stronger treatment is needed.

Does tazarotene make your face peel?

Yes, peeling is a common side effect of tazarotene, especially during the first few weeks of use. Dr. Om explains that this happens because tazarotene speeds up skin cell turnover, causing the top layer of dead skin to shed more quickly. This effect usually lessens as the skin builds tolerance. Using a gentle cleanser, daily moisturizer, and applying the cream as directed can help manage peeling.

Can I switch from tretinoin to tazarotene?

Dr. Om explains that it is possible to switch from tretinoin to tazarotene, but the transition should be done carefully due to tazarotene’s higher potency and irritation potential. Patients who’ve used tretinoin consistently without issues may tolerate tazarotene well. When switching, it’s often recommended to start with the lower strength (0.05%) a few nights per week and gradually increase frequency, while maintaining a good moisturizer to reduce dryness or peeling.

Who should switch from tretinoin to tazarotene?

According to Dr. Om, patients who have plateaued on tretinoin or need stronger results for acne, sun damage, or pigmentation may be good candidates to switch to tazarotene. It’s especially useful for those with thicker or oilier skin types who can better tolerate stronger retinoids. However, it’s not ideal for those with sensitive skin, rosacea, or a history of irritation with retinoids. A dermatologist should guide the switch to make sure it’s done safely and effectively.

Which retinoid is best for anti-aging?

According to Dr. Om, tretinoin has been considered the gold standard retinoid for anti-aging due to its long history of clinical evidence. However, tazarotene is regarded as the most potent topical retinoid and it tends to deliver stronger anti-aging results, particularly for photoaging, though it can be more irritating and is better suited for experienced retinoid users. 

What is stronger than tazarotene?

Dr. Om says that among topical retinoids, there is no prescription option stronger than tazarotene, which is widely considered the most potent topical retinoid used in dermatology.  For acne specifically, the only retinoid considered stronger than topical tazarotene is oral isotretinoin, which works systemically and is used for severe or treatment-resistant acne rather than routine topical therapy.

Request a tazarotene prescription online

Have a consultation with a dermatologist via Miiskin to request a prescription for tazarotene cream and choose between a generic or customized medication.

Start tazarotene consult