Request an adapalene (Differin) prescription

Response time: 1-2 working days

Board-certified dermatologists
Your choice of branded, generic or customized formulas
Service available in all 50 states

Young woman with mild acne holding a tube of adapalene 0.1% gel skincare treatment.

Medically reviewed by:
Dr. Anna Chacon
Dermatologist

Young woman with acne-prone skin holding a tube of adapalene 0.1% gel.

What is adapalene (Differin) and what is it used for?

Adapalene, commonly known by the brand name Differin, is a topical retinoid derived from vitamin A that works by regulating skin cell turnover and reducing inflammation. Adapalene is FDA approved for the treatment of acne vulgaris, including blackheads, whiteheads, and inflammatory acne in individuals 12 years old or older¹. Off-label, dermatologists may recommend adapalene to help improve skin texture, prevent clogged pores, and fade post-inflammatory hyperpigmentation from acne, although it is not FDA approved specifically for anti-aging or scar treatment.

Start consultation

Adapalene RX

A dermatologist may prescribe a compounded adapalene cream prepared by Foothills Pharmacy based on a patient’s individual needs. Simply select Foothills as your pharmacy of choice, and your dermatologist will determine the appropriate adapalene strength and, when clinically appropriate, select additional ingredients based on professional judgment and patient-specific factors such as skin type, sensitivity, and treatment goals.

Important Disclaimer: Compounded medications are not reviewed by the FDA for safety or efficacy.

Start consultation

How to get a prescription for adapalene (generic Differin)?

Do I need a prescription for adapalene?

Adapalene 0.1% gel is available over the counter, while higher strengths (such as adapalene 0.3%) and combination products (like adapalene with benzoyl peroxide or antibiotics) do require a prescription.

How to get a prescription for adapalene online?

You can consult an online dermatologist through Miiskin. If they determine that adapalene (or an adapalene compounded treatment) is appropriate for your skin, they will issue a prescription. New patient consultations are $59, and prescription renewals are $39.

Can I request an adapalene prescription on behalf of my child?

Yes! Via Miiskin, you can do an online consultation on behalf of your child. Simply select “minor” when indicating your “skin problem”. You will be prompted to answer some questions on behalf of your child and take some photos of their skin.

How to buy adapalene online?

Via Miiskin you can have your prescription issued to any pharmacy in the country. If you want a compounded formula, choose Foothills as your preferred pharmacy. Most Foothills formulas are $48.99, with some advanced formulas are $58.99. Once you get your prescription, you can order it right on Miiskin.

Important Disclaimer: Compounded medications are not reviewed by the FDA for safety or efficacy.

Start consultation

How to request a adapalene cream prescription online

Select “Start consultation” to sign-up with Miiskin.
Use the consultation form to request adapalene.
If medically appropriate, you will receive a prescription from a dermatologist.
Purchase your adapalene in the pharmacy of your choice.

Start consultation

Process to getting a prescription for adapalene online
Through an online consultation, you connect with a dermatologist. Upon reviewing your case, if the doctor determines that a cream with adapalene is appropriate for you, they will provide a prescription that you can get from the pharmacy of your choosing.

Why is adapalene often combined with other acne treatments?

Adapalene is often combined with other acne treatments because it targets clogged pores and inflammation. Additional ingredients address different causes of acne at the same time, such as benzoyl peroxide, to kill acne-causing bacteria or antibiotics to reduce bacterial growth and redness. This makes the overall treatment more effective and helps prevent antibiotic resistance when used appropriately.

Common adapalene combination creams

Adapalene + Benzoyl Peroxide

Adapalene + Benzoyl Peroxide + Clindamycin

adapalene and benzoyl peroxide and clindamycin

Adapalene + Clindamycin

Important Disclaimer: Compounded medications are not reviewed by the FDA for safety or efficacy.

Who is adapalene for?

Adapalene is for individuals over 12 years of age who struggle with mild to moderate acne, especially those with blackheads, whiteheads, and inflammatory breakouts, and for patients who need a long-term treatment to prevent clogged pores².

Dr. Chacon explains that it is commonly prescribed for teenagers and young adults with acne-prone or oily skin, and can also be suitable for those with sensitive skin when introduced gradually. It is often prescribed to patients seeking an effective, dermatologist-recommended retinoid.

Who should avoid it/use it with caution?

Adapalene as any other retinoid should be avoided during pregnancy due to its teratogenic risks. Individuals with a significantly compromised skin barrier, such as after recent cosmetic procedures or severe sunburn, should avoid adapalene until the skin has healed.

You should only use it under medical supervision if you have eczema, rosacea, severely irritated or broken skin, or those with a known allergy or hypersensitivity to retinoids or any ingredient in the product.

Adapalene 0.1% is FDA approved for acne in children 12 years and older and is commonly prescribed for adolescents. Children under 12 should only use it if specifically directed by a dermatologist.

How to use adapalene correctly?

According to Dr. Anna Chacon, a board-certified dermatologist, if you have been prescribed with adapalene, this is how you should use it.

1. Cleanse gently

Wash your face with a mild cleanser and lukewarm water.

2. Wait before applying

Wait 10–20 minutes after washing so skin is fully dry (reduces irritation).

3. Use a tiny amount

Squeeze a pea-sized amount for the entire face (not spot-by-spot).

4. Apply a thin layer

Dot on forehead, cheeks, and chin, then spread evenly over acne-prone areas.

5. Avoid sensitive zones

Keep it away from eyes, eyelids, lips, corners of the nose, and broken/irritated skin.

6. Start slowly

Use 2–3 nights/week for 1–2 weeks, then increase to nightly as tolerated.

7. Moisturize

Apply a gentle moisturizer, adapalene, and then moisturizer again if sensitive.

8. Use sunscreen daily

Apply broad-spectrum SPF 50+ every morning, since retinoids can increase sun sensitivity.

9. Avoid mixing with irritants

Do not layer with other retinoids, harsh exfoliants, or alcohol-based products unless directed.

10. Be consistent

Improvements typically appear after 8–12 weeks of regular use.

Adapalene and other medications

Ingredients that can be used alongside adapalene

Gentle moisturizers (ceramides, glycerin, hyaluronic acid)

Sunscreen (SPF 50+) – essential for daily use

Niacinamide – helps calm irritation and support the skin barrier

Benzoyl peroxide – effective for acne (often used in the morning or in fixed combinations)

Clindamycin or other topical antibiotics – reduce acne-causing bacteria (when prescribed)

Ingredients to avoid or use cautiously with adapalene

Other retinoids (tretinoin, retinol, tazarotene) – should not be used together with adapalene

Alcohol-based toners or astringents – avoid as a general rule

Strong exfoliating acids (glycolic acid, lactic acid, high-strength salicylic acid)

Physical scrubs or cleansing brushes – can worsen irritation

Fragranced products – may increase sensitivity

Sulfur or resorcinol – can be overly drying when combined

Harsh acne spot treatments – increase redness, peeling, and discomfort

What patients say about Miiskin

Very happy with this service. Quick and easy. With someone with not the greatest insurance and super busy. This was perfect. Got my prescription next day and great advice for my condition.

Marcus Liniarski,
Patient Review →

I had a great experience with Miiskin – I was able to get my prescription very quickly and their app is easy to use. It was very convenient and their team is very responsive. I highly recommend them and will likely use them in the future for other skin issues.

Susie Tse,
Patient Review →

What a technology! I was very impressed by the speed of communication with a doctor using the Miiskin app. Losing my hair has been my biggest concern, but I didn’t have the courage to reveal my bald spot to a doctor in person. Miiskin solved all my issues instantly. I just took a photo in my own room, uploaded it, and wrote about my concerns. That’s it. The best part is that without insurance, the consultation fee was much lower than any health insurance. I submitted my photo at midnight and received a prescription the very next morning. The doctor at Miiskin was very professional and empathetic, which really helped ease my emotional distress. Although I’m just at the beginning stage of my treatment and haven’t seen significant results yet, I feel reassured and supported. I will definitely upload my progress in 3 to 4 months to show my appreciation for the prescription from Miiskin.

Jiyeon Kang,
Patient Review →

My dermatologist was extremely quick, reviewed my consultation request within 2hrs and I had my Rx the next day! The Miiskin team also responds within minutes and are very polite and communicated concisely. I’ll never make a in person appointment again after experiencing this outstanding and affordable telehealth service!

Dion H,
Patient Review →

Quick response from the dermatologist — I wanted a fast turnaround for a skin concern that would be more immediate than going through health insurance, making an appointment, traveling to the doctor.

Timothy C.
Patient Review →

Provider & Prescription Information

Miiskin connects patients with independent dermatologists who provide care through their private practices. Compounded prescriptions can be ordered via Miiskin and are dispensed by Foothills pharmacy. Standard medications can be issued for any local pharmacy.

Got more questions about getting an adapalene prescription online?

Can a 10 year old use adapalene?

A 10-year-old should not use adapalene unless it is prescribed by a dermatologist. Adapalene is FDA approved for acne in children 12 years and older, and safety data for younger children are limited. In some cases, a dermatologist may recommend it off label if the child has significant acne and other treatments have not worked, but this should always be done under close medical supervision.

How long does it take for adapalene to work?

Dr. Chacon explains that adapalene requires consistency and patience. Most patients begin to see early improvement in acne within four to six weeks, but clearer and more stable results typically take eight to twelve weeks. Continued use is important even if results are not immediate.

Does adapalene cause purging, and how long does it last?

According to Dr. Chacon, adapalene can cause an initial purging phase as clogged pores clear more quickly. This may appear as new breakouts in areas where acne commonly occurs. Purging usually lasts two to six weeks and gradually improves as the skin adjusts.

Can adapalene be used every day?

Dr. Chacon notes that adapalene is intended for daily use, but you should start slowly. Using it two to three nights per week at first helps reduce irritation, with gradual progression to nightly application as tolerated.

Should adapalene be applied in the morning or at night?

Dr. Chacon recommends applying adapalene at night. Evening use reduces the risk of sun-related irritation and allows the medication to work while the skin is in repair mode during sleep.

Can I use moisturizer with adapalene?

Dr. Chacon strongly encourages using a moisturizer with adapalene. Applying a gentle, fragrance-free moisturizer helps protect the skin barrier and minimize dryness. Your moisturizer can be applied before or after adapalene (or both) if your skin is sensitive.

Can adapalene help with blackheads and whiteheads?

Dr. Chacon explains that adapalene is especially effective for blackheads and whiteheads because it normalizes skin cell turnover and prevents pores from becoming clogged.

Is adapalene suitable for sensitive skin?

According to Dr. Chacon, adapalene can be used on sensitive skin with caution. Starting slowly, using a moisturizer at night and sunscreen every morning can help sensitive skin tolerate treatment more comfortably.

Can adapalene be used on the body (chest, back, shoulders)?

Dr. Chacon says adapalene can be used on body acne such as the chest, back, and shoulders. A thin layer should be applied to clean, dry skin, and patients should expect similar dryness or irritation as on the face.

Does adapalene help with acne scars or dark spots?

Dr. Chacon notes that adapalene does not treat deep acne scars, but it can help fade post-inflammatory dark spots over time by increasing cell turnover and improving overall skin texture.

Can teenagers use adapalene?

Dr. Chacon explains that adapalene is commonly used in teenagers and is approved for adolescent acne. It is often a first-line treatment for mild to moderate acne in this age group.

What happens if I stop using adapalene?

According to Dr. Chacon, stopping adapalene does not cause harm, but acne may gradually return since the medication helps prevent new clogged pores. Maintenance use is often needed for long-term control.

Can adapalene be combined with benzoyl peroxide or antibiotics?

Dr. Chacon states that adapalene is frequently combined with benzoyl peroxide or topical antibiotics to improve acne outcomes. These combinations target different acne causes and are often used together safely when directed.

Does adapalene make skin more sensitive to the sun?

Dr. Chacon explains that adapalene can increase sun sensitivity. Daily use of broad-spectrum sunscreen with SPF 50 on your face is essential to prevent sunburn and irritation.

Is dryness and peeling normal when starting adapalene?

According to Dr. Chacon, mild dryness, peeling, and redness are common during the first few weeks. These effects usually improve as the skin adjusts, especially with proper moisturizing.

How much adapalene should I use per application?

Dr. Chacon advises using only a pea-sized amount for the entire face. Using more does not improve results and increases the risk of irritation.

How much does adapalene cost?

Over-the-counter adapalene 0.1% gel often costs around $10–$25 per small tube. Prescription versions may cost significantly more without insurance. If you are interested in a compounded adapalene formula, you can choose Foothills as your preferred pharmacy and your dermatologist will issue a prescription to Foothills. Most Foothills formulas are $48.99.

Do you need a prescription for adapalene?

Dr. Chacon explains that adapalene 0.1% is available over the counter in the U.S., while higher strengths (such as 0.3%) and combination products require a prescription.

Is 0.1% adapalene stronger than 1% retinol?

According to Dr. Chacon, 0.1% adapalene is more potent and more effective than 1% retinol because adapalene is a retinoid that binds more selectively to retinoid receptors, making it more effective for acne or anti-aging.

Does adapalene build collagen?

Dr. Chacon notes that adapalene’s primary role is acne treatment, but it can indirectly support collagen over time by increasing cell turnover and reducing inflammation, though it is not as collagen-stimulating as tretinoin.

What should I avoid while using adapalene?

Dr. Chacon advises avoiding other retinoids, harsh exfoliants, alcohol-based toners, physical scrubs, and excessive sun exposure, as these can increase irritation and skin barrier damage.

Is adapalene safe during pregnancy?

Dr. Chacon states that adapalene is not recommended during pregnancy. Even though systemic absorption is low, topical retinoids are generally avoided due to potential teratogenic risk.

Who cannot use adapalene?

According to Dr. Chacon, adapalene may not be appropriate for pregnant individuals, those with eczema or severely compromised skin barriers, or people with known retinoid hypersensitivity, unless directed by a healthcare professional.

Is adapalene like Accutane?

Dr. Chacon clarifies that adapalene is not like Accutane. Adapalene is a topical retinoid used on the skin, while Accutane (isotretinoin) is an oral medication with systemic effects and significantly higher risk, including strict pregnancy prevention requirements.

Start a virtual consultation to request a custom adapalene cream

Start consultation

References:
¹https://www.ncbi.nlm.nih.gov/books/NBK482509/
²https://www.mayoclinic.org/drugs-supplements/adapalene-topical-route/description/drg-20061544