Top prescription ointments and creams for eczema – Online access made easy 

Table of Content:
How to get a prescription for eczema online? | Best prescription ointments | Strongest prescription steroid cream | Systemic medications | Antihistamines | FAQ

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Can I get an eczema prescription online?

Yes. With Miiskin, you can consult an independent online dermatologist who can diagnose eczema and prescribe treatment, along with care for other skin conditions. New patient consultations cost $59–$69, and prescription renewals are $30 – $39.

How to get a prescription for eczema online?

Click the banner below or download the Miiskin app to start your online consultation. After completing the consultation, you’ll receive your prescription within 1–2 days. You can then order your medication online or pick it up at your local pharmacy. 

Please be aware you can only receive a prescription for topical treatment and antihistamines via Miiskin. Your provider cannot prescribe systemic medication for eczema via telehealth a consultation.

What are the best prescription ointments and creams for eczema?

Dr. Sarita Nori, a board-certified dermatologist providing care through the Miiskin platform, says that the best prescription treatments for eczema depend on the severity, location, and age of the patient. Commonly prescribed options include low-potency corticosteroids like hydrocortisone for sensitive areas, mid-potency steroids such as triamcinolone for body flares, and stronger agents like clobetasol for short-term use on thick, stubborn patches. Non-steroidal options—such as tacrolimus, pimecrolimus, crisaborole, and the newer ruxolitinib cream—are valuable for delicate skin (eg. eyelids) or for long-term maintenance without the risk of skin thinning¹. Your dermatologist will choose the most appropriate medication based on your symptoms, flare pattern, and skin needs.

Hydrocortisone 2.5%

• Price: Varies ($10–$30 Rx generic)
• Potency: Low
• Age: All ages (OTC ≥2 yrs typical label)
• Prescriptions: ✅ Yes
• Where to Use: ✅ Safe for face, folds, groin, and children
• Summary: Mild steroid for small eczema flares. Minimal side effects when used short-term. Apply a thin layer to the affected area before using a moisturizer².

Triamcinolone acetonide 0.1%

• Price: $5–$25 generic
• Potency: Medium
• Age: varies
• Prescriptions: ✅ Yes
• Where to Usea: ❌ Not for face/folds; best for trunk/limbs
• Summary: Common mid-strength steroid for moderate eczema flares on body. Avoid prolonged use to prevent skin thinning³.

Clobetasol propionate 0.05%

• Price: $15–$60 generic
• Potency: High
• Age: Adults; specialist use in < 18yo
• Prescriptions: ✅ Yes
• Where to Use: ❌ Not for face/folds; short bursts on thick skin (palms/soles)
• Summary: Strong steroid for severe, thick eczema plaques. High risk of side effects with overuse—use only as prescribed⁴.

Tacrolimus ointment (Protopic)

• Price: $50–$200 generic (insurance dependent)
• Class: Topical calcineurin inhibitor
  Age: 0.03% ≥2 yrs; 0.1% ≥16 yrs
• Prescriptions: ✅ Yes
• Where to Use: ✅ Excellent for delicate skin (face, eyelids, folds)
• Summary: Steroid-sparing option for sensitive areas. Temporary burning common at start; no skin thinning risk⁵.

Pimecrolimus 1% cream (Elidel)

• Price: $200–$300 (brand; generics less common)May be cheaper with goodrx coupon if not covered by insurance. 
• Class: Topical calcineurin inhibitor
• Age: ≥2 yrs
• Prescriptions: ✅ Yes
• Where to Use: ✅ Face/eyelids; folds; mild–moderate eczema where steroids not preferred
• Summary: Steroid-sparing option for sensitive skin. Similar to tacrolimus but lighter, cream-based. Commonly used in children and for long-term maintenance; may cause mild burning/stinging at first⁶.

What is the strongest prescription steroid cream for eczema?

Dr. Nori says that the strongest prescription topical steroids available for eczema are clobetasol propionate 0.05% (brands include Temovate and generic versions) and betamethasone dipropionate (Diprolene brand name). They are classified as  high potency corticosteroids and  typically used only for short periods—often just a few days to two weeks—on thick, stubborn eczema patches such as those on the hands, feet, or other non-sensitive skin areas⁷. It should not be used on the face, skin folds, or groin due to the higher risk of side effects, which can include skin thinning, stretch marks, and other local reactions. Because of their potency, they are usually prescribed when milder steroids haven’t worked, and always under close medical supervision (with minimal to no refills).

Are there systemic medications for eczema?

Dr. Nori explains that there are several oral and injection medications available for eczema, particularly for moderate to severe cases that don’t respond well to topical treatments. The safest options are injection medications that have been shown to be very safe (Dupixent, Adbry, Ebglyss and Nemluvio). Newer oral treatments include oral JAK inhibitors such as upadacitinib (Rinvoq)⁸ and abrocitinib (Cibinqo)⁹, which are more broadly immunosuppressive but also very safe for most people. These medications require blood tests to be monitored regularly. These all target specific immune pathways to reduce inflammation and itching quickly. Prednisone is still used for very short term acute relief, as a bridge to a maintenance eczema topical regimen. Dr. Nori notes that it is important to be aware that it is usually not possible to get a prescription for these medications with a  telehealth consultation as all systemic  treatments require medical supervision and regular monitoring.
Your provider cannot prescribe systemic medications for eczema via Miiskin.

When are  systemic  medications used for eczema/ atopic dermatitis?

According to Dr. Nori systemic medications for eczema are typically considered when the condition is moderate to severe, widespread, or significantly impacting quality of life, and when topical treatments alone are not enough. These medications may also be used if eczema is recurring frequently or causing constant itching and sleep disturbance despite appropriate topical care. Because systemic  medications work throughout the body and can affect the immune system, their use is carefully weighed against potential side effects, and they are prescribed only under close dermatologist supervision.
Your provider cannot prescribe systemic medications for eczema via Miiskin.

What antihistamines are usually used for eczema relief?

Dr. Nori explains that while antihistamines do not treat the underlying inflammation of eczema, they can be helpful for breaking the itch cycle (itching and scratching causes rashes to worsen), especially when it interferes with sleep. Commonly used sedating antihistamines include diphenhydramine (Benadryl) and hydroxyzine (Atarax, Vistaril), which are typically taken at night to help break the itch–scratch cycle and improve rest. Non-sedating antihistamines, such as cetirizine (Zyrtec), loratadine (Claritin), or fexofenadine (Allegra), may also be used during the day if itching is persistent. She notes that these medications are generally considered adjunctive therapy—most effective when combined with proper skin care and prescription topical treatments.

Antihistamines can be prescribed via a telehealth consultation.

FAQ about prescription ointments and medications for eczema

What cream gets rid of eczema fast?

Dr. Nori says that no cream can permanently “get rid” of eczema, but some treatments can calm a flare quickly. For many people, medium-to high-potency prescription steroid creams or ointments—such as triamcinolone or mometasone—can reduce redness and itching within a few days. In severe cases, super-high potency steroids like clobetasol may be prescribed for short-term use on thick skin areas. A course of prednisone tablets can also provide some quick relief. For the fastest improvement, these medications are often paired with thick moisturizers or ointments (like petroleum jelly, Aquaphor, or ceramide creams) applied several times a day to restore the skin barrier. The best choice depends on the eczema’s location, severity, and your overall skin sensitivity—so a dermatologist’s guidance is key. In addition, Dr. Nori stresses that since eczema is a chronic condition, it sometimes requires ongoing maintenance and topical prescription therapy; there are three main prescription creams used for this; tacrolimus ointment, pimecrolimus cream and Eucrisa ointment. These are non-steroid medications safe to use on any part of the body and can be safely used for extended periods to keep eczema flares under control. A common treatment regimen is to calm down the flare up with a 2-3 week course of strong topical steroid and/or prednisone + antihistamines, and then use tacrolimus ointment for maintenance. Moisturizing, avoiding allergens and irritants (fragrance-free soaps and laundry detergents), and antihistamines (if there is a history of seasonal allergies) are necessary to treat all forms of eczema. 

What are the best OTC creams and ointments for eczema?

For over-the-counter eczema relief, Dr. Nori often recommends fragrance-free, cream  moisturizers and ointments that restore the skin barrier and lock in moisture. Popular options include petrolatum-based ointments (like Vaseline or Aquaphor), colloidal oatmeal creams (such as Aveeno Eczema Therapy), and ceramide-rich moisturizers (like CeraVe Moisturizing Cream, Eucerin Eczema Relief or La Roche Posay Lipikar balm). For mild flare-ups, an OTC hydrocortisone cream can reduce redness and itching when used short-term on non-sensitive skin areas. Apply moisturizers at least twice daily, especially after bathing, to help prevent flare-ups and maintain skin hydration. One of the most important components of skin care for eczema is to miminize the use of soaps; anything that foams destroys the lipids and anti-bacterials your skin works hard to make. Dr. Nori says that the skin makes an anti-bacterial enzyme that is more effective at combating resistant forms of bacteria than prescription antibiotics. When you wash your skin daily with soap or body wash, these are all being washed down the drain. So use soap only on hands, feet and armpits and rinse your body with lukewarm water only. Avoid all products with fragrance and artificial color if you have eczema,  including soaps, body washes, and laundry detergents. 

Is there a new treatment for eczema?

Dr. Nori says several new nonsteroidal topical prescription options are now available—most are brand-only and are very costly without insurance. Zoryve (roflumilast 0.15% cream) is a once-daily, steroid-free anti-inflammatory for atopic dermatitis¹⁰. VTAMA (tapinarof) 1% cream is another nonsteroidal option approved for eczema¹¹. Opzelura (ruxolitinib) 1.5% cream, a topical JAK inhibitor, can reduce itch quickly for even moderate eczema¹².

Dr. Nori explains that while these newer treatments expand options, older medications—such as topical corticosteroids and calcineurin inhibitors—remain highly effective for most patients and are far more affordable. Because of their proven track record, safety when used as directed, and lower cost, they are still the most widely prescribed therapies for eczema.

What is eczema that won’t go away?

Dr. Nori explains that eczema that doesn’t improve despite consistent treatment may be due to ongoing exposure to triggers such as skin contact allergies (not the same as allergies to pollen or foods), recurrent infections, incorrect diagnosis, or underlying skin infections that worsen inflammation. In some cases, the eczema may be more severe or chronic, requiring a change in treatment—such as stronger topical medications, nonsteroidal creams, or even systemic injection or oral chronic medication. She emphasizes that persistent eczema should be reassessed by a dermatologist to confirm the diagnosis and adjust the care plan.

Does Vaseline help eczema?

According to Dr. Nori, plain petroleum jelly—such as Vaseline—can be very effective for eczema because it locks in moisture and strengthens the skin barrier. It is especially helpful for dry, cracked skin and can be applied liberally after bathing to seal in hydration. While it doesn’t directly treat inflammation, Vaseline can reduce flare frequency and help other medications work better when used as part of a daily moisturizing routine.

Can I do a virtual visit for eczema?

Dr. Nori confirms that virtual visits are an excellent option for many eczema patients. Through teledermatology platforms like Miiskin, patients can share detailed photos and medical history, receive a diagnosis, and be prescribed appropriate treatments. 

Your provider can only prescribe topical medication for eczema via Miiskin.

How to get eczema medication online?

Dr. Nori advises that eczema medication can be obtained through a consultation with an online dermatologist, via Miiskin. The Miiskin platform allows dermatologists to view close-up photos of the skin and medical history, which enables dermatologists to assess the severity, location, and type of eczema, then prescribe topical or oral medications as needed. Prescriptions can be sent to a local pharmacy or ordered through an online service for home delivery. She stresses the importance of using medications exactly as directed for the best results. And she recommends doing a follow up visit on Miiskin, in the timeframe recommended by the dermatologist. Often dermatologists will treat the acute episode and then check in 3-6 weeks later to see if and what maintenance regimen may be required.

Your provider can only prescribe topical medication for eczema via Miiskin.

Is eczema an immune disease?

Dr. Nori explains that eczema, or atopic dermatitis, is considered a chronic inflammatory skin condition with an immune system component. In people with eczema, the immune system overreacts to triggers—such as allergens, irritants, or microbes—causing skin inflammation, itching, and barrier dysfunction. While genetics and environmental factors also play a role, the immune dysregulation is a key reason why targeted immune therapies can be effective in treatment¹³.

How to treat extreme cases of eczema?

According to Dr. Nori, extreme cases of eczema require a comprehensive approach that may include prescription topical medications, phototherapy, oral or injectable immune-modulating drugs, and aggressive moisturization. Identifying and avoiding triggers, treating any skin infections, and maintaining daily skin barrier care are also critical. Severe eczema usually requires multiple in-person visits and often a multi-disciplinary approach with allergists and sometimes rheumatologists to find the best solution. 

Why did my doctor not prescribe an oral medication for eczema?

Dr. Nori explains that apart from a short course of prednisone, the oral medications for eczema are generally reserved for more severe cases because they affect the entire immune system and carry a higher risk of side effects. They require baseline blood work which have to be repeated a few times a year. Similarly injection medications also require consistent monitoring for efficacy and side effects.  It’s a matter of balancing how much the eczema is affecting quality of life vs. the low but present risks of systemic medications. Besides, some oral therapies require regular lab monitoring, and insurance coverage may be limited. Dr Nori stresses however that dermatologists are trained on the extensive medical literature about the impact skin diseases have on quality of life, and that it is simply not possible to “not itch”. Itch can be a disabling symptom, sometimes worse than pain, and dermatologists get that. She recommends discussing ongoing symptoms with a dermatologist to determine whether systemic medications are appropriate and which settings those might best be prescribed in.

Article References:
https://nationaleczema.org/treatments/topicals/
https://my.clevelandclinic.org/health/drugs/18748-hydrocortisone-cream-lotion-ointment-or-solution
https://www.medicalnewstoday.com/articles/triamcinolone-acetonide-cream-for-eczema
https://my.clevelandclinic.org/health/drugs/19019-clobetasol-ointment
https://my.clevelandclinic.org/health/drugs/19514-tacrolimus-ointment
https://www.webmd.com/drugs/2/drug-22383/elidel-topical/details
https://www.verywellhealth.com/steroids-topical-steroid-strengths-1068832
https://www.rinvoqhcp.com/
https://www.cibinqo.com/
https://www.zoryve.com/
https://vtama.com/
https://www.opzelura.com/atopic-dermatitis/what-is-opzelura
https://www.ncbi.nlm.nih.gov/books/NBK538209/