Buy hydroquinone 4 % cream with an online prescription

Response time: 1-2 working days

Board-certified dermatologists
Option for generic or personalized formulas
No medication subscriptions

Medically reviewed by:
Dr. Eric Howell
Dermatologist

What is hydroquinone 4 % cream?

Hydroquinone 4% cream is a prescription-strength skin-lightening treatment used to reduce melasma, hyperpigmentation, age spots, and other forms of unwanted dark patches on the skin. It works by blocking tyrosinase, the enzyme responsible for melanin production, thereby slowing down the creation of new pigment and gradually lightening existing discoloration. Because of its strength, it’s considered one of the most effective topical treatments for stubborn pigmentation, but it should be used under medical supervision to avoid side effects and to ensure safe, targeted results¹.

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What is hydroquinone 4 % cream used for?

Hydroquinone is used to lighten dark spots on the skin.

Melasma

Age spots/sun spots

Post-inflammatory hyperpigmentation

Evening skin tone

Freckles (small, brown spots caused by sun exposure and genetics)

Hyperpigmented acne scars

Hydroquinone 4 % brands

Tri-Luma
Lustra
Melquin HP 4%
Alphaquin
Eldoquin
Melanex
Solaquin

Dermatologist-guided compounded care

Through Miiskin, you can connect with a dermatologist who may prescribe a compounded formula, personalized with multiple active ingredients tailored to your individual plan.

Patients often explore ingredient options with their providers — which may include tretinoin, hydroquinone, or other compounds.

No subscription plans. You pay only for the services and medications prescribed.

Important Disclaimer: Compounded medications are not reviewed by the FDA for safety or efficacy.

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How to buy hydroquinone 4 % cream online?

Can you buy hydroquinone 4 % cream over the counter ?

No you cannot buy hydroquinone cream 4 % over the counter, you need a doctor’s prescription, which means you need to have an online consultation with a dermatologist.

How to get an online prescription for hydroquinone cream 4 %?

You can book an online consultation with a board-certified dermatologist through Miiskin. If you’re new to hydroquinone 4% cream—or haven’t used it in the past year—a dermatologist can evaluate your skin and prescribe it if it’s safe and appropriate for you.

What is the price of getting a hydroquinone 4 % cream prescription online?

Getting an online prescription for hydroquinone 4 % is fairly simple via Miiskin. New patient consultations are $59 and prescription renewals are $30. You then need to buy your medication at a local or compounding pharmacy.

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How to request a hydroquinone 4% cream prescription online

Select “Start consultation” to sign-up with Miiskin.
Use the consultation form to request hydroquinone.
If medically appropriate, you will receive a prescription from a dermatologist.
Purchase your hydroquinone in the pharmacy of your choice.

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Process to getting hydroquinone 4% cream online
With Miiskin, you can consult a board-certified dermatologist online using photos of your skin. The dermatologist will evaluate your case, decide if hydroquinone is right for you, and issue a prescription. If you choose a compounded formula, it can be ordered through a mail-order pharmacy and delivered to your door; if you opt for a generic version, you can fill it at your local pharmacy.

How is hydroquinone 4 % cream different from other skin-lightening ingredients?

Hydroquinone is a topical skin-lightening agent that is different from other creams for hyperpigmentation in several ways.

Clinically proven

Decades of research back hydroquinone as the gold standard treatment for hyperpigmentation, while many creams rely on less studied actives.

among the most effective lightening agents for the skin

Stronger potency

Hydroquinone directly blocks melanin production, making it more powerful than most over-the-counter brightening agents.

Faster, targeted results

Hydroquinone works more quickly and effectively on stubborn dark spots and melasma compared to natural or cosmetic-grade alternatives.

Prescription-only strength

Unlike common creams with ingredients like niacinamide or vitamin C, hydroquinone 4% requires a doctor’s prescription for safe use.

Hydroquinone 4% benefits

Very effective at treating melasma and hyperpigmentation³
Inhibits the production of melanin²
Delivers consistent skin lightening results⁴
Offered as combination cream for improved results

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What patients say about Miiskin

Very happy with this service. Quick and easy. With someone with not the greatest insurance and super busy. This was perfect. Got my prescription next day and great advice for my condition.

Marcus Liniarski,
Patient Review →

I had a great experience with Miiskin – I was able to get my prescription very quickly and their app is easy to use. It was very convenient and their team is very responsive. I highly recommend them and will likely use them in the future for other skin issues.

Susie Tse,
Patient Review →

What a technology! I was very impressed by the speed of communication with a doctor using the Miiskin app. Losing my hair has been my biggest concern, but I didn’t have the courage to reveal my bald spot to a doctor in person. Miiskin solved all my issues instantly. I just took a photo in my own room, uploaded it, and wrote about my concerns. That’s it. The best part is that without insurance, the consultation fee was much lower than any health insurance. I submitted my photo at midnight and received a prescription the very next morning. The doctor at Miiskin was very professional and empathetic, which really helped ease my emotional distress. Although I’m just at the beginning stage of my treatment and haven’t seen significant results yet, I feel reassured and supported. I will definitely upload my progress in 3 to 4 months to show my appreciation for the prescription from Miiskin.

Jiyeon Kang,
Patient Review →

My dermatologist was extremely quick, reviewed my consultation request within 2hrs and I had my Rx the next day! The Miiskin team also responds within minutes and are very polite and communicated concisely. I’ll never make a in person appointment again after experiencing this outstanding and affordable telehealth service!

Dion H,
Patient Review →

Quick response from the dermatologist — I wanted a fast turnaround for a skin concern that would be more immediate than going through health insurance, making an appointment, traveling to the doctor.

Timothy C.
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Side effects and Warnings

Possible side effects of hydroquinone 4 % cream

Dryness, itching, or a burning sensation on the skin
Thinning of the skin, which may increase the risk of bruising
Changes in skin tone
Scaling or flaking around the mouth
Blisters or flaking on treated areas
Redness and irritation
Rash development
Peeling of the skin⁵

Precautions when using hydroquinone 4 %

Hydroquinone 4% cream should always be used with caution and under medical supervision. It is intended for short-term treatment only, as prolonged use can increase the risk of side effects such as ochronosis, a bluish-gray skin discoloration.

Hydroquinone 4 % can make the skin more sensitive to sunlight, therefore, daily sunscreen is essential to protect against further pigmentation. Some users may experience irritation, redness, or peeling, especially at the start of treatment, so it should never be applied to broken, inflamed, or eczematous skin. A patch test is recommended before regular use to check for allergic reactions. Women who are pregnant or breastfeeding should not use hydroquinone as safety during pregnancy and breastfeeding has not been fully established.

How to use hydroquinone 4% cream?

According to Dr. Eric Howell, board-certified dermatologist, here are some guide general guidelines on how to apply hydroquinone 4% cream.

Cleanse the skin

Gently wash the treatment area with a mild cleanser, rinse thoroughly, and pat the skin completely dry before applying the cream.

Wash your hands

After each application, wash your hands thoroughly with soap and water to avoid spreading the cream to unintended areas.

Skip broken skin

Do not apply the cream on cuts, abrasions, eczema patches, or any inflamed or irritated skin to reduce the risk of irritation.

Apply sparingly

Use only a thin, even layer of hydroquinone 4% cream and limit application to the specific dark spots or areas of hyperpigmentation.

Use daily sunscreen

Protect your skin with a broad-spectrum sunscreen every morning, since hydroquinone can make the skin more sun-sensitive.

Allow time for results

Be consistent with treatment and allow at least 4–8 weeks of regular use before expecting to see visible improvements.

Provider & Prescription Information

Miiskin connects patients with independent dermatologists who provide care through their own private practices. Miiskin does not employ dermatologists and does not sell or distribute medications. Any prescriptions issued by the dermatologists can be filled at third-party pharmacies of the patient’s choice.

FAQ about hydroquinone 4% cream

What is Hydroquinone 4% cream?

Hydroquinone 4% cream is a prescription-strength skin-lightening treatment used to reduce melasma, age spots, and other forms of hyperpigmentation.

How does Hydroquinone 4% cream work?

It works by inhibiting an enzyme called tyrosinase, which reduces melanin production in the skin and gradually lightens dark patches.

Do I need a prescription for Hydroquinone 4%?

Yes. In the United States, hydroquinone 4% is prescription-only and must be prescribed by a licensed healthcare provider.

How can I get a Hydroquinone 4% prescription online?

You can book an online consultation with a board-certified dermatologist via Miiskin. If it’s safe and appropriate, they will issue your prescription digitally.

Where can I buy Hydroquinone 4% cream?

Once you have a prescription, you can buy hydroquinone 4% at a local pharmacy. If prescribed as a compounded formula, it can be ordered through a mail-order pharmacy and delivered to your home.

How do I use Hydroquinone 4% cream?

Apply a thin layer directly to the dark spots once or twice daily, as directed by your dermatologist. Always wash your hands after use and avoid applying it to unaffected skin.

How long does it take to see results with hydroquinone 4%?

Most people notice visible improvement within 4–8 weeks of consistent use, though results may vary depending on the severity of pigmentation.

Can Hydroquinone 4% be used long-term?

No. It is typically recommended for short-term use (around 3 months), as prolonged application can increase the risk of side effects like ochronosis.

Is sunscreen necessary while using Hydroquinone 4%?

Yes. Sunscreen is essential, as hydroquinone makes skin more sensitive to UV light and sun exposure can worsen pigmentation.

Can Hydroquinone 4 % be used during pregnancy or breastfeeding?

It is generally not recommended during pregnancy or breastfeeding, as safety has not been fully established. Always consult your doctor first.

Is Hydroquinone 4% safe for all skin types?

It can be effective for many skin types, but people with darker skin tones may be at higher risk of side effects such as ochronosis. A dermatologist should guide its use.

What’s the difference between Hydroquinone 2% and 4%?

Hydroquinone 2% is lower strength and sometimes available over-the-counter, while 4% is stronger, prescription-only, and more effective for stubborn pigmentation.

Can I use Hydroquinone 4% with other skincare products?

Yes, but avoid using it with harsh exfoliants or irritating products unless approved by your dermatologist. Often, it is combined with tretinoin and a mild steroid for enhanced results.

What should I do if I miss a dose of hydroquinone 4% cream?

Simply apply it at the next scheduled time. Do not double the amount to make up for a missed application.

Start a virtual consultation to request a custom hydroquinone 4% cream

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References:
¹https://www.ncbi.nlm.nih.gov/books/NBK539693/
²https://www.ncbi.nlm.nih.gov/books/NBK539693/
³https://pubmed.ncbi.nlm.nih.gov/12709008/
⁴https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9122278/
⁵https://my.clevelandclinic.org/health/drugs/19764-hydroquinone-skin-cream-gel-emulsion-lotion-or-solution