Tri Luma®: Price, patient coupons, and getting an online prescription to buy it
Tri Luma is a highly-effective prescription cream used for moderate to severe melasma. Learn how to get the best price, patient coupons, and how to get a prescription for Tri Luma with an online dermatology provider for a more even skin tone.
Table of Content:
Tri Luma price without coupons | Best Tri Luma coupon | Is Tri Luma OTC? | Can you get a generic Tri-Luma? | What is Tri Luma? | Ingredients | How to use it? | Side-effects | Why was it taken of the market?

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Tri Luma® cream is a powerful prescription treatment for people with moderate to severe melasma, a common skin condition causing dark patches on the face. If you are seeking a more even skin tone and are wondering about the cost and availability of Tri Luma, you have come to the right place. In this article, we will explore various aspects, including the price considerations, patient assistance coupons, and the process of obtaining a prescription for Tri Luma.
Discover how you can access this highly-effective treatment conveniently through online dermatology providers, ensuring a smoother journey towards achieving the even skin complexion you desire.
Can I buy Tri Luma over the counter (OTC)?
No, Tri Luma, or any other cream that includes hydroquinone in its formula cannot be bought over the counter (OTC) you need a doctor’s prescription to get it.
What is the price of Tri Luma when paid out of pocket?
The average price of a branded 30 gr tube of Tri-luma® cream in the U.S. varies from $180 to $250*.
*The price range listed here is just an estimation. Tri Luma cream prices may vary depending on the state and the pharmacy selected. Miiskin is not responsible and cannot influence the price of the medication as it is independent from these entities.
How to get the best Tri Luma coupon?
The best Tri Luma coupon and the best price can be obtained with the Galderma Care Connect Patient Card which allows you to get a 30 gram tube of Tri Luma for $90.
How to get a Tri Luma prescription?
If you want to get a prescription for branded Tri Luma, you can have a consultation with a board-certified dermatologist via Miiskin. You just need to answer a clinical questionnaire, upload some photos of your skin and mention in the consultation that you want either a prescription for Tri Luma.
Where can I buy Tri Luma?
Once you have gotten a prescription from your dermatologist, you can go to the pharmacy of your choice and buy it there. This flexibility allows you to find the best drug prices in your area.
About Tri Luma
What is Tri Luma and what is it used for?
Tri Luma cream is an FDA-approved topical prescription medication used for the treatment of moderate to severe melasma2, a skin condition characterized by the appearance of brown to gray-brown patches on the face which is more frequent in women. These patches appear on the cheeks, chin, nose bridge, forehead, and above the upper lip. Oral contraceptives or pregnancy are known causes of melasma3.
How long do I have to use Tri Luma for?
Tri Luma cream is mostly prescribed for a short period of time (8 weeks). During this time you should experience a considerable reduction in the discoloration of your skin and you should begin seeing results as early as 4 weeks1.
One 30 gr tube should be enough for an 8-week treatment on your face, however it depends on how large is the skin area you want to treat.
What are the ingredients of Tri Luma?
Tri Luma cream combines three active ingredients:
- Fluocinolone acetonide is a corticosteroid that helps reduce inflammation and irritation in the skin4.
- Hydroquinone is a first-line treatment used for depigmentation or skin lightening agent, it works by inhibiting the production of melanin, the pigment responsible for skin color. Hydroquinone is used in the treatment of melasma (chloasma), solar lentigines (age spots), freckles, and post-inflammatory hyperpigmentation (due to acne, eczema, psoriasis or scars)5.
- Tretinoin: Tretinoin is a retinoid that promotes skin cell turnover and helps to exfoliate the skin. It is used to treat facial wrinkles, skin roughness and hyperpigmentation while improving the overall appearance of the skin6.
Why is Tri Luma so effective against hyperpigmentation?
The combination of the three ingredients in Tri Luma cream work together to address the different aspects of melasma, including reducing inflammation, inhibiting melanin production, and promoting skin cell turnover7 8.
How to use Tri Luma?
Tri Luma cream should only be used under the supervision of a healthcare provider, as it is a prescription medication and may have potential side effects or interactions with other medications.
However, according to Dr. Anna Chacon, board-certified dermatologist, as a general rule, the Tri Luma cream is typically applied once daily (during the night) to the affected areas of the face and body.

What are the side effects of Tri Luma?
- Skin irritation, redness and peeling
- Itching and dryness
- Potential infection of the skin or hair follicles
- Acne
- Changes in skin color
- Skin inflammation
- Allergic skin reaction or rashes
- Skin thinning
- Stretch marks
- Increased sweat9
References:
https://www.triluma.com/triluma-cream
https://pubmed.ncbi.nlm.nih.gov/25989732/
https://www.ncbi.nlm.nih.gov/books/NBK459271/
https://my.clevelandclinic.org/health/drugs/19482-fluocinolone-skin-cream-ointment-or-topical-solution
https://www.ncbi.nlm.nih.gov/books/NBK539693/
https://www.ncbi.nlm.nih.gov/books/NBK557478/
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021112s006lbl.pdf
https://www.fdanews.com/ext/resources/files/archives/g/Galderma.pdf
https://www.prnewswire.com/news-releases/galdermas-tri-luma-cream-only-fda-approved-treatment-for-melasma-now-available-in-pharmacies-190833881.html