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Home / Acne / Medications / Topical Spironolactone

Understanding compounded topical spironolactone

Board-certified dermatologist Dr. Carolina Fernandez, tells you everything you need to know about topical spironolactone and how to use it for hormonal acne.

Dermatologist  Dr. Carolina Fernandez Quiroga
Medically reviewed by:
Dr. Carolina Fernandez Quiroga
Dermatologist

Table of Content:
What is topical spironolactone? | Is it used for acne? | Do you need a prescription? | How to get it? | Benefits | Side-effects | Oral vs topical spironolactone | FAQ

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Our commitment to producing high-quality content:

The information presented in this article is based on scientific research and the professional advice of our Content Medical Reviewers, who are experts in the field of Dermatology. How we write our content →


What is topical spironolactone?

Spironolactone is an FDA-approved oral medication for certain conditions. Some healthcare providers also prescribe compounded topical formulations prepared by licensed pharmacies. These topical versions are not FDA-approved and have not been evaluated by the FDA for safety or efficacy.

Is topical spironolactone used for acne?

Some dermatologists may consider prescribing compounded topical spironolactone formulations for select patients during a consultation. These prescriptions are individualized and prepared by a licensed compounding pharmacy.

Important Notice: Compounded topical spironolactone is not reviewed or approved by the FDA for safety or effectiveness. Suitability and use are determined only by a licensed provider following a consultation.

Do you need a doctor’s prescription to buy topical spironolactone?

Yes, you need a prescription to buy topical spironolactone cream, as it is not available over the counter.

How to get an online prescription via Miiskin?

Miiskin connects you with board-certified dermatologists, who may prescribe FDA-approved generics or personalized compounded medications.

If prescribed, your compounded formula may include up to five active ingredients, selected by your dermatologist as part of your treatment plan. After receiving your prescription, you can order it through a reputable online pharmacy. If you are interested in a personalized formula, you can discuss this option with your dermatologist during your consultation.

Transparent pricing: A consultation is typically around $59, and medication refills are around $39. You pay separately for your prescription at the pharmacy when you order it. There are no automatic subscriptions — you only purchase medication when you need it.

Important Disclaimer: Compounded medications are not reviewed by the FDA for safety or efficacy.

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Where are prescriptions filled?

If a provider prescribes a compounded topical formula, it is prepared and dispensed by a licensed compounding pharmacy.

Is topical topical spironolactone used for acne?

Compounded topical spironolactone has been discussed in dermatology as one of several possible ingredients that some providers may consider when treating patients with acne. These topical versions are prepared by licensed compounding pharmacies.

At this time, the FDA has not reviewed topical spironolactone for safety or effectiveness, and there is no standardized formulation. Some research and clinical use have explored its role in dermatology, but results vary and suitability depends on the individual patient.

If you are interested in whether a compounded topical formula that includes spironolactone might be appropriate for you, the decision must be made in consultation with a licensed healthcare provider.

Important Notice: Compounded topical spironolactone is not reviewed or approved by the FDA for safety or efficacy. Not all patients will receive a prescription. Suitability and potential risks are determined by the prescribing provider during consultation.

articles about spironolactone topical for acne

Topical Spironolactone for Acne

  • Topical spironolactone: Dermatologist Guide
  • Spironolactone: How long to work?
  • Tretinoin & spironolactone for hormonal acne

Topical spironolactone side effects

Because compounded topical spironolactone is not FDA-approved, its full safety profile has not been established. Patients should discuss any potential risks with their prescribing provider.

Reported side effects of topical spironolactone may include:

  • Redness
  • Itching
  • Irritation
  • Burning sensation
  • Dryness or scaling
custom rx treatment

Get a prescription for personalized skincare

Have an online consultation with a dermatologist to get personalized prescription skincare designed just for you!

Get a personalized prescription

FAQ about topical spironolactone

Does topical spironolactone cause purging?

Although it is rare for topical spironolactone to trigger an initial outbreak of acne, an acne flare-up may affect very few patients when they first start using spironolactone.

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Can spironolactone be used orally and topically at the same time?

A healthcare provider will determine the most appropriate prescription approach for each patient.

Who should not use topical spironolactone for acne?

Topical spironolactone is antiandrogenic and these medications are not  recommended for use during pregnancy or breastfeeding as it is not safe for the baby. 

Get a topical spironolactone prescription for your acne

Get an online prescription for topical spironolactone for acne or hair loss from a board-certified dermatologist.

Get topical spironolactone

Article References:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763909/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8483163/
https://pubmed.ncbi.nlm.nih.gov/36412248/#
https://www.ncbi.nlm.nih.gov/books/NBK554421/
https://www.sciencedirect.com/science/article/pii/S1110116416300333
https://www.dovepress.com/the-efficacy-and-safety-of-oral-and-topical-spironolactone-in-androgen-peer-reviewed-fulltext-article-CCID
https://pubmed.ncbi.nlm.nih.gov/34250269/
https://www.bmj.com/content/381/bmj.p1114#

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Miiskin is an online dermatology consultations platform that connects patients with independent dermatologists.

All consultations are provided by independent online dermatologists on a cash-pay-only basis. Miiskin does not practice medicine or pharmacy. Prescriptions, if applicable, are sent to third-party pharmacies, which are paid directly for any medication. Medication images on the website are for illustrative purposes only and images of people are not actual patients. Medical information on miiskin.com is for informational purposes and not medical advice. Consult a healthcare provider for any concerns.

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