Buy tretinoin cream 0.05 % with an online prescription

Response time: 1-2 working days

Board-certified dermatologists
Option for generic or personalized formulas
No medication subscription

Medically reviewed by:
Dr. Eric R. Howell
Dermatologist

topical tretinoin 0.05 for skin rejuvenation

What does tretinoin cream 0.05 % do?

Tretinoin cream 0.05 % is a prescription-strength retinoid that speeds up skin cell turnover to treat acne, smooth fine lines, fade dark spots, and improve overall skin texture. By boosting collagen production and unclogging pores, it not only helps clear existing breakouts but also prevents new ones while supporting healthier, more even-looking skin over time.

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What is tretinoin 0.05 % cream used for?

Tretinoin 0.05 % is used for the treatment of:

Acne

Smooth skin texture

Improve post-inflammatory hyperpigmentation

Melasma

Wrinkles

Brand names of tretinoin 0.05 %

Altreno lotion 0.05%
Atralin cream 0.05%
Refissa cream 0.05%
Retin-A cream 0.05%

Get a customized skincare formula

Some patients prefer customized formulas to simplify their skincare routines. Miiskin connects you with board-certified dermatologists who can prescribe personalized compounded treatments, tailored with up to 5 active ingredients.

During your consultation, your dermatologist may discuss various ingredient options — such as tretinoin, hydroquinone, niacinamide, or others — depending on your individual treatment plan.

No subscriptions. No hidden fees. Just pay for the care and medication you need—only when you need it.

Disclaimer: Compounded medications are not reviewed by the FDA for safety or efficacy.

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what sets tretinoin 0.05 distinct from other strengths of creams

How is tretinoin 0.05 % different from other cream strengths?

Tretinoin 0.05% has a medium concentration which means it can be used by individuals with sensitive skin who have already been using tretinoin for a while or in some cases, it can be used as a starting dose, especially with versions that are less irritating such Retin-A Micro, Altreno or compounded formulas with tretinoin and niacinamide, tretinoin 0.05%.

How to buy tretinoin cream 0.05 %?

Do you need a prescription to buy tretinoin cream 0.05 %?

Yes, tretinoin 0.05% requires a prescription. With Miiskin, you can easily request it by having an online consultation with a board-certified dermatologist.

How to get an online prescription for tretinoin 0.05?

You can have a consultation with an online dermatologist through Miiskin. The consultation price is $59 for new patients and around $30 for prescription refills. You will get an answer in 1-2 days.

How to buy tretinoin 0.05 then?
After you have been issued your prescription you can buy it at a local pharmacy. If you have indicated you want a customized tretinoin-based formula you will be indicated to buy it via compounding online pharmacy.

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acquire a prescription for 0.05 tretinoin

Faster results

An increased concentration can potentially provide more noticeable and faster skin improvements. It also implies more stronger side effects.

More effective

Due to its higher concentration, tretinoin 0.05% may be more successful in treating various skin concerns, such as acne, fine lines, wrinkles, and hyperpigmentation.

Stronger side effects

While tretinoin 0.05% can produce better outcomes, it is also associated with a higher risk of producing skin irritation, dryness, redness, and sensitivity.

Gradual introduction

Tretinoin 0.05% is typically recommended for people who who have already tried and become accustomed to lower-strength tretinoin products.

Getting a tretinoin 0.05 % cream is very simple with Miiskin

Sign-up with Miiskin by pressing “Start your consultation”.
Download the Miiskin app and request tretinoin 0.05% in the consultation form.
It will be prescribed to you by a dermatologist, if medically appropriate.
Buy your tretinoin 0.05% from the pharmacy of your choosing.

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Process to getting a prescription for tretinoin 0.05%
You can use the Miiskin app to connect with a healthcare provider through online consultation. If the doctor determines, after reviewing your case, that tretinoin 0.05% is the recommended dosage for you, the doctor will write a prescription for it, which you may pick up from any pharmacy.

Benefits of tretinoin 0.05 %

Reduces fine lines and wrinkles

Repairs sun damage on skin

Enhances skin texture

Promotes a more uniform skin tone

Aids in minimizing breakouts

Anti-inflammatory characteristics

Warning and precaution when using tretinoin 0.05 cream

It is highly recommended that all women who take tretinoin creams and gels with a concentration of 0.05, higher or lower use effective contraception while using tretinoin.

Tretinoin is classified as teratogenic, which means that women who are planning to become pregnant, are currently pregnant, or are breastfeeding, should not use it, since it carries significant risks to the developing fetus.

Tretinoin 0.05% heightens the skin’s susceptibility to sunlight; therefore, it is essential to apply sunscreen with an SPF rating of at least 50 each morning while using this product. Please reapply it every two hours when exposed to sunlight.

The usage of this medication should be exclusively under the supervision of a licensed healthcare professional.

Potential side effects associated with tretinoin 0.05 cream

Even though tretinoin 0.05% has a medium concentration you may still be affected with a few side effects such as peeling and dryness, particularly if this is your first time using retinoid.

Skin irritation
Dryness
Increased sun sensitivity
Temporary worsening of acne

Skin sensitivity
Redness
Peeling
Stinging or burning sensation

Does tretinoin .05 % cause a purge even if you have been using tretinoin for a while?

According to Dr. Howell, you can experience a “tretinoin purge” even if you have been using tretinoin for a while, especially if you started with a lower concentration and you increase it to tretinoin 0.05%.

The tretinoin purge is a transient skin reaction that can occur when you initiate tretinoin use or switch to a higher concentration. It may manifest as an initial deterioration of acne, the emergence of new pimples, or heightened redness and inflammation in the treated areas.

This phenomenon typically arises because tretinoin accelerates the skin’s natural exfoliation process, leading to the expulsion of accumulated debris and impurities from the pores. While this process ultimately contributes to clearer and smoother skin, it may initially worsen acne or provoke breakouts.

The tretinoin purge represents a common aspect of the adjustment period when employing tretinoin, particularly at elevated strengths. It is usually a temporary phase, varying in duration from a few weeks to several months, depending on individual factors. It is generally advisable to adhere to the prescribed treatment regimen recommended by your healthcare provider, as the skin typically demonstrates improvement once it has adapted to the medication.

How to minimize the severity and length of the tretinoin purge?

Read our Dermatologist’s guide on How to use tretinoin correctly.

How to start using tretinoin cream 0.05 %?

Although you should always follow your doctor’s advice, here’s an excellent place to start when increasing the strength of tretinoin.

First 2 to 4 weeks:
Apply a moisturizing cream with hyaluronic acid or niacinamide, wait 10 minutes then apply tretinoin cream 0.05% two nights per week in the evenings followed by another layer of moisturizer.
Following 5 to 10 weeks:
Apply tretinoin every other night. Apply a moisturizing cream with hyaluronic acid or niacinamide, wait 10 minutes then apply tretinoin cream 0.05% followed by another layer of moisturizer.
After 12 weeks of use:
Apply the product every night using the sandwich approach (layering between moisturizer) if your skin accepts the product nicely.

However, is is possible that the daily application of tretinoin will cause irritation to your skin, as it is very strong. Use common sense, if your skin is overly dry or irritated skip tretinoin that night and use only a moisturizing cream containing hyaluronic acid or niacinamide instead.

Provider & Prescription Information

Miiskin connects patients with independent dermatologists who provide care through their own private practices. Miiskin does not employ dermatologists and does not sell or distribute medications. Any prescriptions issued by the dermatologists can be filled at third-party pharmacies of the patient’s choice.

Start a virtual consultation to request Tretinoin 0.05%

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Got more questions about tretinoin 0.05 or getting a tretinoin prescription online?

Is tretinoin 0.05% available over the counter?

No. Tretinoin 0.05% is not available over the counter and can only be purchased with a doctor’s prescription.

How much does it cost to get a prescription for tretinoin 0.05%?

Having a consultation via Miiskin to get a tretinoin 0.05 prescription is around $59 for new patients and $39 for retuning patients who need a medication refill.

How to buy tretinoin 0.05% cream or gel online?

After your dermatologist has issued your prescription you can buy it at a local pharmacy. If you have mentioned during your consultation that you want a personalized tretinoin-based formula, you will need to buy your compounded formula via an online pharmacy that ships nationwide.

Do I have to pay separately for the consultation and the tretinoin 0.05%?

Yes, the consultation fee is $59 for new patients and $39 for existing patients in need of a refill. Then you need to buy your medication via a third-party online pharmacy.

How long does tretinoin 0.05 take to show results?

Tretinoin 0.05 usually takes 8–12 weeks for noticeable improvements, with continued benefits over several months.

Can I use other skincare products with tretinoin 0.05?

Yes, you can use other skincare products while using tretinoin 0.05, but you need to be selective. Tretinoin 0.05 can increase skin sensitivity, so combining it with strong exfoliants like glycolic acid, salicylic acid, or benzoyl peroxide may cause irritation, redness, or excessive dryness. It’s generally best to keep your routine simple: use a gentle cleanser, a nourishing moisturizer, and always apply tretinoin 0.05 at night. If you want to add serums or exfoliants, consult your dermatologist first to ensure they are safe to use alongside tretinoin 0.05.

Do I need sunscreen while using tretinoin 0.05?

Yes, daily sunscreen is absolutely essential when using tretinoin 0.05. This medication increases cell turnover, which makes your skin more sensitive to UV rays and more prone to sunburn and irritation. Without proper sun protection, you may experience redness, peeling, or worsening dark spots. A broad-spectrum sunscreen with SPF 30 or higher should be applied every morning, even on cloudy days. Consistent sunscreen use not only protects your skin but also ensures tretinoin 0.05 works effectively to improve texture, acne, and signs of aging.

Is tretinoin 0.05 suitable for all skin types?

Tretinoin 0.05 can be effective for many skin types, including oily, acne-prone, and mature skin, but not everyone tolerates it the same way. People with sensitive or very dry skin may experience more irritation, peeling, or redness, especially during the first few weeks of treatment. For these skin types, dermatologists often recommend starting with a lower strength before moving to tretinoin 0.05 or using it less frequently at first (e.g., every other night). With proper adjustment and support from a dermatologist, most people can eventually benefit from tretinoin 0.05.

Can pregnant or breastfeeding women use tretinoin 0.05?

No, tretinoin 0.05 should not be used during pregnancy or breastfeeding. Tretinoin is a form of vitamin A (a retinoid), and oral retinoids like isotretinoin are known to cause birth defects. While the risk from topical tretinoin 0.05 is considered lower, it is still not recommended due to potential safety concerns. If you are pregnant, planning to become pregnant, or breastfeeding, speak with your doctor about safe alternatives for managing acne, pigmentation, or anti-aging concerns. Options such as azelaic acid or glycolic acid may be considered instead of tretinoin 0.05.